Paul Okunieff, M.D.


Chairman of the Department of Radiation Oncology
Philip Rubin Professor of Radiation Oncology
Department of Radiation Oncology
M.D., Harvard Medical School, 1982
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Contact Information:

Office: Med G-3310
University of Rochester Cancer Center
Department of Radiation Oncology
601 Elmwood Ave, Box 647
Rochester, NY 14642

Phone: (585) 275-5575
Fax: (585) 275-1531
E-mail: paul_okunieff@urmc.rochester.edu

Biographical Sketch

Dr. Paul Okunieff completed his Bachelors of Science in Biology and a Bachelors in Science in Electrical Engineering and Computer Science at MIT in 1978. He obtained his MD from Harvard Medical School in the HST (Health, Science & Technology) Program in 1982. His MD Thesis focused on the role that anti-oxidants might play in preventing radiation toxicity and improving tumor response to radiation. After completing a residency and chief residency in Radiation Oncology at the Massachusetts General Hospital in 1985, he continued on as a Fellow and then Instructor and Assistant Professor at Harvard Medical School. In 1991, he became the Chief of Radiation Neuro-Oncology at Massachusetts General Hospital and, concurrently, was Co-Director of Radiation Oncology in Boston at University Hospital. In 1993, he became Branch Chief of Radiation Oncology at the National Cancer Institute, where he was responsible for all radiobiology, radiation clinical protocol development, radiation medical director and directorship of medical physics. In 1997, he assumed the role of the Chairman of Radiation Oncology and Philip Rubin Professor at the University of Rochester School of Medicine and Dentistry.

Clinical Specialty
Research Overview
Selected Honors
Education
Academic Appointments
Hospital Appointments
Major Committees
Publications
Radiation Oncology Home

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Clinical Specialty

Dr. Okunieff, with the assistance of the radiation oncology Fellows, is responsible for introducing and developing new innovative techniques, and supervising the Orange Service, which includes high dose brachytherapy, 3D treatment planning, and stereotactic radiosurgery. Clinical protocols include an oligometastasis protocol for curative radiosurgical treatment of metastatic breast cancer. He also directs the RTOG Office at the University of Rochester with five affiliated hospitals around the country. He is the Translational Research Chair of the RTOG.

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Research Overview

Dr. Okunieff's major research interest is the role that growth factors and cytokines play in ameliorating or promoting radiation toxicity.

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Selected Honors

  • 2001 Davey Memorial Award for Outstanding Contributions to Cancer Research, URCC 6th Annual Symposium, Rochester, NY.
  • 1998 International Del Regato Conference, Memorial Art Gallery, Rochester, NY.
  • 1991 Melvin H. Knisely Award: International Society on Oxygen Transport to Tissue, Curacau, Netherlands Antilles.
  • 1990 USNC/UICC Travel Grant Award: UICC Meeting, Hamburg, Germany.
  • 1989 Basic Science Travel Grant: ASTRO Annual Meeting, San Francisco, CA.
  • 1988 Young Investigator Travel Award: VIth International Meeting on Chemical Modifiers of Cancer Treatment, Paris, France.
  • 1987 American College of Radiology Travel Award: First Conference on Predictors of Cancer Treatment Response, Banff, Canada.
  • 1987 American Radium Society Young Oncologist Essay Award, London, England.
  • 1978 Institute of Electrical and Electronic Engineers (IEEE) Essay Award, Boston, MA.


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Education

  • 1985-1986 Chief Resident in Radiation Medicine, Massachusetts General Hospital, Boston, MA
  • 1983-1986 Resident, Radiation Medicine, Massachusetts General Hospital, Boston, MA
  • 1982-1983 Intern, Internal Medicine, Beth Israel Hospital, Boston, MA
  • 1982 M.D. Harvard Medical School
  • 1978 B.S. Biological Sciences, Massachusetts Institute of Technology
  • 1978 B.S. Electrical Engineering and Computer Science, Massachusetts Institute of Technology


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Academic Appointments

  • 1997-present Philip Rubin Professor of Radiation Oncology, University of Rochester School of Medicine & Dentistry, Rochester, NY
  • 1995-present Adjunct Professor, George Washington University School of Medicine
  • 1993-1997 Branch Chief, Radiation Oncology Branch, National Cancer Institute, Bethesda, MD
  • 1993-1997 Adjunct Associate Professor in Radiation Oncology, Georgetown University Medical School, Washington, DC
  • 1988-1993 Assistant Professor in Radiation Oncology, Harvard Medical School
  • 1987 Instructor in Radiation Medicine, Harvard Medical School


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Hospital Appointments

  • 2001-present Associate Director for Clinical Research, James P. Wilmot Cancer Center, University of Rochester, Rochester, NY
  • 2000-present Director, Robert A. Flavin Radiosurgery Center, University of Rochester, Rochester, NY
  • 1997-present Chair, Department of Radiation Oncology, University of Rochester, Rochester, NY
  • 1997-present Committee on the Status of Women, University of Rochester, Rochester, NY
  • 1997-present Ad Hoc Committee for Promotions, University of Rochester, Rochester, NY
  • 1997-2001 Chair, Protocol Review Committee of University of Rochester Cancer Center, University of Rochester, Rochester, NY
  • 1997-2001 Promotions Committee, University of Rochester, Rochester, NY
  • 1993-1998 Radiation Safety Committee Member, National Institute of Health, Bethesda, MD
  • 1991-1993 Chief, Radiation Neuro-oncology, Massachusetts General Hospital, Boston, MA
  • 1990-1991 Co-Director, Department of Radiation Therapy, University Hospital, Boston, MA
  • 1990 Associate Radiation Oncologist, University Hospital, Boston, MA
  • 1989 Assistant Radiation Therapist, Mt. Auburn Hospital, Cambridge, MA
  • 1989 Assistant Radiation Therapist, Waltham Hospital Medical Center, Waltham, MA
  • 1987 Assistant Radiation Therapist, Massachusetts General Hospital, Boston, MA


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Major Committees

  • 2003 President, International Society on Oxygen Transport to Tissue (ISOTT)
  • 2002-present SWOG Radiation Therapy Committee Chair
  • 2001 Consultant, Special Study Section, Review of Competing Renewal of Research Resource application, Hanover, NH
  • 2000-present Peer Review Committee Chair
  • 1999-2002 IE NCIC Canadian Grant Review Committee (Member 99,00 Chair 01, 02)
  • 1997-present RTOG Translational Research Program Chair
  • 1997-present RTOG Tumor Biology Co-Chair
  • 1997 International Society on Oxygen Transport to Tissue (Exec Committee)
  • 1997 NCI Workshop: Molecular Biology in Radiation Research
  • 1997 American Association for Cancer Research (Member)
  • 1996 Search Committee for Chair of Radiology and Radiologic Sciences
  • 1995-present Am. Soc. Therapeutic Radiation Oncologists (Abstract committee)
  • 1995-present Radiation Research Society (Nominating committee)
  • 1993-present National Institutes of Health, Radiation Safety Committee
  • 1993-1997 National Cancer Institute, Institutional Review Board (IRB)
  • 1991 International Stereotactic Radiosurgical Society (Charter Member)
  • 1989 Committee on Research, Massachusetts General Hospital
  • 1988 International Society on Oxygen Transport to Tissue (Member)
  • 1986 North American Hyperthermia Group (Member)
  • 1986 Radiation Research Society (Member)
  • 1986 Society of Magnetic Resonance in Medicine (Member)
  • 1984 American Society of Therapeutic Radiology and Oncology (Member)
  • 1984-1993 New England Society of Radiation Oncology (Member)


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Publications

  1. Okunieff P, Koutcher J, Gerweck L, McFarland E, Urano M, Hitzig B, Neuringer L, Suit H. Tumor size dependent metabolic changes in a murine fibrosarcoma: use of Fourier transform 31P NMR to evaluate tumor energy metabolism. Int J Radiat Oncol Biol Phys 12: 793-799, 1986.
  2. Okunieff P, Suit H, Proppe K. Extremity preservation by combined modality treatment of sarcomas of the hand and wrist. Int J Radiat Oncol Biol Phys 12: 1923-1929, 1986.
  3. Koutcher J, Okunieff P, Neuringer L, Suit H, Brady T. Size dependent changes in tumor phosphate metabolism after radiation therapy as detected by 31P NMR spectroscopy. Int J Radiat Oncol Biol Phys 13: 1851-1855, 1987.
  4. Okunieff P, McFarland E, Rummeny E, Willett C, Hitzig B, Neuringer L, Suit H. Effects of oxygen on the metabolism of murine tumors using in-vivo phosphorus-31 NMR. Am J Clin Oncol 10: 475-482, 1987.
  5. Okunieff P, Suit H. Toxicity, radiation sensitivity modification, and combined drug effects of ascorbic acid with misonidazole in-vivo on FSaII murine fibrosarcomas. J Natl Cancer Inst 79: 377-381, 1987.
  6. Urano M, Todoroki T, Kahn J, Okunieff P. The effect of hyperglycemia on the tumor response to irradiation given alone or in combination with hyperglycemia. Radiat Res 111: 488-497, 1987.
  7. Willett C, Urano M, Suit H, Strauss H, Kahn J, Okunieff P. The effect of temperature on the tumor blood flow and on the size of hypoxic cell fraction in a murine fibrosarcoma in C3Hf/Sed mice. Int J Radiat Oncol Biol Phys 13: 1309-1312, 1987.
  8. Okunieff P, Kallinowski F, Vaupel P, Neuringer L. Effect of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in-vivo 31P-nuclear magnetic resonance spectroscopy. J Natl Cancer Inst 80: 745-750, 1988.
  9. Okunieff P, Ramsay J, Tokuhiro T, Hitzig B, Rummeny E, McFarland E, Neuringer L, Suit H. Estimation of tumor oxygen and metabolic rate using 31P MRS: correlation of spin-lattice relaxation with tumor growth rate and DNA synthesis. Int J Radiat Oncol Biol Phys 14: 1185-1195, 1988.
  10. Okunieff P, Rummeny E, Vaupel P, Skates S, Willett C, Neuringer L, Suit H. Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in-vivo 31P-nuclear magnetic resonance spectroscopy. Radiat Res 115: 361-372, 1988.
  11. Vaupel P, Okunieff P. Role of hypovolemic hemoconcentration in dose-dependent flow decline observed in murine tumors after intraperitoneal administration of glucose or mannitol. Cancer Res 48: 7102-7106, 1988.
  12. Johnson D, Nishimura M, Okunieff P, Kazemi H, Hitzig B. Effects of hyperthermia on rat brain pHi and phosphate metabolite regulation by 31P NMR. Am J Physiol 67: 2527-2534, 1989.
  13. Kallinowski F, Schlenger K, Runkel S, Kloes M, Stohrer M, Okunieff P, Vaupel P. Blood flow, metabolic functions, cellular microenvironment and growth rate of human tumor xenografts. Cancer Res 49: 3759-3764, 1989.
  14. Kalmus J, Okunieff P, Vaupel P. Effect of ip versus iv glucose administration on laser Doppler flow in murine FSaII tumors and normal skin. Cancer Res 49: 6313-6317, 1989.
  15. Nishimura M, Johnson D, Hitzig B, Okunieff P, Kazemi H. The effect of hypercapnia on brain cell pH and high energy phosphate levels in rats by 31P NMR. J Appl Physiol 66: 2181-2188, 1989.
  16. Okunieff P, Vaupel P, Sedlacek R, Neuringer L. Evaluation of tumor energy metabolism and microvascular blood flow after glucose or mannitol administration using 31P magnetic resonance spectroscopy and laser Doppler flowmetry. Int J Radiat Oncol Biol Phys 16: 1493-1500, 1989.
  17. Okunieff P, Walsh C, Vaupel P, Kallinowski F, Hitzig B, Neuringer L, Suit H. Effects of hydralazine on in-vivo tumor energy metabolism, hematopoietic radiation sensitivity, and cardiovascular parameters. Int J Radiat Oncol Biol Phys 16: 1145-1148, 1989.
  18. Schwartz L, Okunieff P, Rosenberg A, Suit H. Radiation therapy in the treatment of difficult giant cell tumors. Int J Radiat Oncol Biol Phys, 17, 1085-1088, 1989.
  19. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 49: 6449-6465, 1989.
  20. Vaupel P, Okunieff P, Kallinowski F, Neuringer L. Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma. Radiat Res 120: 477-493, 1989.
  21. Vaupel P, Okunieff P, Kluge M. Response of tumor red blood cell flux to hyperthermia and/or hyperglycemia. Int J Hyperthemia 5: 199-210, 1989.
  22. Okunieff P, Vaupel P, Neuringer L. 31P nuclear magnetic resonance measurements of ATPase kinetics in malignant tumors. Adv Exptl Med Biol 248: 819-828, 1989.
  23. Vaupel P, Okunieff P, Neuringer L. Blood flow, tissue oxygenation, pH distribution, and energy metabolism of murine mammary adenocarcinomas during growth. Adv Exptl Med Biol 248: 835-846, 1989.
  24. Evans F, Levine R, Okunieff P. Detection of malignant tumors by 1H nuclear magnetic resonance spectroscopy of plasma. Eur J Cancer 26: 5-7, 1990.
  25. Kalmus J, Okunieff P, Vaupel P. Dose dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSaII tumors. Cancer Res 50: 15-19, 1990.
  26. Miralbell R, Zietman A, Okunieff P, Suit H. Fractionation sensitivity and immunological status in radiation treated murine sarcomas. Int J Radiat Oncol Biol Phys 18: 867-872, 1990.
  27. Okunieff P, Greenberg M, Zietman A, Kahn J, Westgate S, Neuringer L. Failure of 1H NMR spectroscopy of blood plasma to detect malignancy. J Clin Oncol 8: 906-910, 1990.
  28. Okunieff P, Zietman A, Kahn J, Singer S, Neuringer L, Levine R, Evans F. Lack of efficacy of water-suppressed proton nuclear magnetic resonance spectroscopy of plasma for detection of malignant tumors. New Engl J Med 322: 953-958, 1990.
  29. Vaupel P, Okunieff P, Neuringer L. In-vivo 31P-NMR spectroscopy of murine tumors before and after localized hyperthermia. Int J Hyperthermia 6: 15-31, 1990.
  30. Okunieff P, Tokuhiro T, Vaupel P, Neuringer L. Interactions of oxygen partial pressure and energy metabolism with the relaxation rate of inorganic phosphate: 31P NMR study. Adv Exptl Med Biol 277: 95-105, 1990.
  31. Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen consumption and tissue oxygenation of human tumors. Adv Exptl Med Biol 277: 895-906, 1990.
  32. Nishizawa K, Okunieff P, Elmaleh D, McKusick K, Strauss H, Suit H. Blood flow of human soft tissue sarcomas measured by thallium-201 scanning: prediction of tumor response to radiation. Int J Radiat Oncol Biol Phys 20: 593-597, 1991.
  33. Okunieff P, Urano M, Kallinowski F, Neuringer L, Vaupel P. Tumors growing in irradiated tissue: oxygenation, metabolic state, and pH. Int J Radiat Oncol Biol Phys 21: 667-673, 1991.
  34. Okunieff P, Dols S, Lee J, Singer S, Vaupel P, Neuringer L. Angiogenesis determines blood flow, metabolism, growth rate and ATPase kinetics: 31P and 2H NMR studies. Cancer Res 51: 3289-3295, 1991.
  35. Zietman A, Suit H, Okunieff P, Donnelly S, Dietman S, Webster S. The life shortening effects of treatment with Doxorubicin and/or local irradiation on a cohort of young C3Hf/Sed mice. Eur J Cancer 27: 778-781, 1991.
  36. Okunieff P. Interactions between ascorbic acid and the radiation of bone marrow, skin and tumor. Am J Clin Nutr 5: 1281S-1283S, 1991.
  37. Suit H, Skates S, Taghian A, Okunieff P, Efird J. Clinical implications of heterogeniety of tumor response to radiation therapy. Radiother Oncol 25: 251-60, 1992.
  38. Okunieff P, Lee J, Itoh M, Vaupel P. Measurements of tumor blood flow using intraperitoneal deuterium and 2H-NMR spectroscopy. Adv Exptl Med Biol 316: 373-384, 1992.
  39. Vaupel P, Schlenger K, Hoeckel M, Okunieff P. Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients. Adv Exptl Med Biol 316: 361-371, 1992.
  40. Okunieff P, Lee J, Vaupel P. Measurement of human tumor blood flow: a positron technique using an artifact of high energy radiation therapy. Adv Exptl Med Biol 317: 169-176, 1992.
  41. Schaefer C, Okunieff P, Vaupel P. Oxygenation and bioenergetic status of murine fibrosarcomas. Adv Exptl Med Biol 3l7: 161-167, l992.
  42. Taghian A, Ramsay J, Allalunis-Turner J, Budach W, Gioioso D, Pardo F, Okunieff P, Bleehan N, Urtasun R, Suit H. Intrinsic radiation sensitivity may not be the major determinant of the poor clinical outcome of glioblastoma multiforme. Int J Radiat Oncol Biol Phys 25: 243-249, 1993.
  43. Dahlberg W, Little J, Suit H, Fletcher J, Okunieff P. Radiosensitivity in vitro of human soft tissue sarcoma cell lines and skin fibroblasts derived from the same patients. Int J Radiat Biol 63: 191-198, 1993.
  44. Okunieff P, Hoeckel M, Dunphy E, Schlenger K, Knoop C, Vaupel P. Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 26: 631-636, 1993.
  45. Singer S, Okunieff P, Gostin C, Thilly W, Chen L, Neuringer L. 13C and 31P-NMR studies of human colon cancer in-vitro and in-vivo. Surg Onc 2: 7-l8, l993.
  46. Okunieff P, Dunphy E, Hoeckel M, Terris D, Vaupel P. The role of oxygen tension distribution on the radiation response of human breast carcinoma. Adv Exptl Med Biol 345: 485-492, 1994.
  47. Hitzig B, Perng W, Burt T, Okunieff P, Johnson D. 1H NMR measurement of the fractional dissociation of imidazole in intact animals. Am J Physiol Mar:266(3 Pt 2): R1008-15, 1994.
  48. Okunieff P, Froio J, Soni S, Kahn J, Gerweck L, Zlotecki R, Abraham E. Tumor growth retardation and pathophysiological effects of ATP therapy measured by thallium washout, 31P NMR, laser doppler flowmetry, and intradermal angiogenesis. Radiat Oncol Invest l: 346-360, l994.
  49. Pardo F, Aronen H, Kennedy D, Moulton G, Paiva K, Okunieff P, Schmidt E, Hochberg F, Harsh G, Fischman A, Linggood R, Rosen B. Functional cerebral imaging in the evaluation and radiotherapeutic treatment planning of patients with malignant glioma. Int J Radiat Oncol Biol Phys l994.
  50. Vaupel P, Schaefer C, Okunieff P. Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi. NMR. Biomed 7: l28-l36, l994.
  51. Epstein A, Lebovics R, Goffman T, Teague D, Fuetsch E, Glatstein E, Okunieff P, Cook J. Treatment of locally advanced cancer of the head and neck with 5'-iododeoxyuridine and hyperfractionated radiation therapy: measurement of cell labeling and thymidine replacement. J Natl Cancer Inst 86: 1775-1780, 1994
  52. Bizzi A, Movsas B, Tedeschi G, Phillips C, Okunieff P, Alger J, DiChiro G. Response of non-Hodgkin's lymphoma to radiation therapy: early and long-term assessment with h-l mr spectroscopic imaging. Radiology 194: 271-276, 1995.
  53. Johnson E, Linnoila R, Williams J, Venzon D, Okunieff P, Anderson G, Richardson G. Risk of second aerodigestive cancers increases in patients surviving free of small-cell lung cancer for more than two years. J Clin Onc 13: 101-111, 1995.
  54. Froio J, Abraham E, Soni R, Epstein A, Okunieff P. Effect of intraperitoneal ATP on tumor growth and bone marrow radiation tolerance. Acta Oncologica 34: 419-422, 1995.
  55. Okunieff P, Abraham E, Moini M, Snyder M, Gloe T, Capogrossi M, Ding I. Basic fibroblast growth factor radioprotects bone marrow and not RIF1 tumor. Acta Oncologica 34: 435-438, 1995.
  56. Jacobson J, Danforth D, Cowan K, D'Angelo T, Steinberg S, Pierce L, Lippman M, Lichter A, Glatstein E, Okunieff P. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage 1 and 11 breast cancer. New Engl J Med 332: 907-911, 1995.
  57. Okunieff P, Morgan D, Niemierko A, Suit H. Radiation dose response of human tumors. Int J Radiat Oncol Biol Phys 32: 1227-1237, 1995.
  58. Miller R, van de Geijn J, Raubitschek A, Orr K, Okunieff P, Glatstein E. Dosimetric considerations in treating mediastinal disease with mantle fields: characterization of the dose under mantle blocks. Int J Radiat Oncol Biol Phys 32: 1083-1095, 1995.
  59. Movsas B, Movsas T, Steinberg S, Okunieff P. Long-term visual changes following pituitary irradiation. Int J Radiat Oncol Biol Phys 33: 599-605, 1995.
  60. Ding I, Moini M, Aotsuka N, Thoolen M, Reilly T, Okunieff P. In vivo radioprotective effects of basic fibroblast growth factor (FGF2) in total body irradiated C3H/HeNCr mice. Radiat Oncol Invest 4: 9-16, 1996.
  61. Harms S, Radenski P, Sunshine J, Davis D, Okunieff P, Farr C, Spettell C. MRI efficacy and effectiveness research: who needs it and who pays for it? J Mag Reson Imag JMRI 1: 4-6, 1996.
  62. Abraham E, Ding I, Vos P, Kahn J, Grubman A, Jefferson D, Okunieff P. Cystic fibrosis hetero-and homozygosity inhibition of breast cancer growth. Nature Medicine 2: 593-596, 1996.
  63. Okunieff P, Wu T, Huang K, Ding I. Differential radioprotection of three mouse strains by basic or acidic fibroblast growth factor. Br J Cancer 74: S105-S108, 1996.
  64. Okunieff P, de Bie J, Dunphy E, Terris D, Hockel M. Oxygen distributions partly explain the radiation response of human squamous cell carcinomas. Br J Cancer 74: S185-S190, 1996.
  65. Greig J, Miller R, Okunieff P. An approach to dose measurement for total body irradiation. Int J Radiat Oncol Biol Phys 36: 463-468, 1996.
  66. Beatty J, Biggs P, Gall K, Okunieff P, Pardo F. A new miniature x-ray device for interstitial radiosurgery: dosimetry. Med Phys 23: 53-62. 1996.
  67. Douglas R, Beatty J, Gall K, Valenzuela R, Biggs P, Okunieff P, Pardo F. Dosimetric results from a feasibility study of a novel radiosurgical source for irradiation of intracranial metastases. Int J Radiat Oncol Biol Phys 36: 443-450, 1996.
  68. Neta R, Okunieff P. Cytokine-induced Radiation Protection and Sensitization. Seminars in Radiation Oncology 6: 306-320, 1996.
  69. Ding I, Huang K, Snyder M, Cook J, Zhang L, Wersto N, Okunieff P. Tumor growth and tumor radiosensitivity in mice given myeloprotective doses of fibroblast growth factors. J Natl Cancer Inst 88: 1399-1404, 1996.
  70. Morris A, Morris R, Wilson J, White J, Steinberg S, Okunieff P, Arriagada R, Le M, Blichert-Toft M, van Dongen J. Breast conserving therapy vs. mastectomy in early stage breast cancer: a meta-analysis of 10 year survival. Cancer J Sci Amer 3: 6-12, 1997.
  71. Ding I, Huang K, Wang X, Greig J, Miller R, Okunieff P. Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments. Acta Oncol 36: 337-340, 1997.
  72. Ding I, Wu T, Matsubara H, Magae J, Shou M, Cook J, Okunieff P. Acidic fibroblast growth factor (FGF1) increases survival and hematopoietic recovery in total body irradiated C3H/HeNCr mice. Cytokine 9: 59-65, 1997.
  73. Abraham E, Okunieff P, Scala S, Vos P, Oosterveld M, Chen A, Shrivastav B. Cystic fibrosis transmembrane conductance regulator and adenosine triphosphate. Science 275: 1324-1326, 1997.
  74. Hu H, Stavrou S, Baker B, Tornatore C, Scharff J, Okunieff P, Neville D. Depletion of T lymphocytes with immunotoxin retards the progress of experimental allergic encephalomyelitis in Rhesus monkeys. Cell Immunol 177: 26-34, 1997.
  75. Chen A, Okunieff P, Pommier Y, Mitchell J. Mammalian DNA topoisomerase I mediates the enhancement of radiation cytotoxicity by camptothecin derivatives. Cancer Res: 57: 1529-1536, 1997.
  76. Walther M, Delaney T, Smith P, Friauf W, Thomas G, Shawker T, Vargas M, Choyke P, Linehan W, Abraham E, Okunieff P, Glatstein E. Phase I trial of photodynamic therapy in the treatment of recurrent superficial transitional cell carcinoma of the bladder. Urology 50: 199-206, 1997.
  77. Chute J, Venzon D, Hankins L, Okunieff P, Frame J, Ihde D, Johnson B. Outcome of patients with small-cell lung cancer during 20 years of clinical research at the US National Cancer Institute. Mayo Clinic Proceedings 72: 901-912, 1997.
  78. Movsas B, Barrows M, Steinberg S, Middleton L, Okunieff P, Jaffee E, Epstein A. Response during radiotherapy may be associated with outcome in mediastinal Hodgkin's disease. Radiat Oncol Invest 6: 216-225, 1998.
  79. Okunieff P, Mester M, Maddox T, Coffee M, Ding I. In vivo radioprotective effects of angiogenic factors on the small bowel of C3H mice. Radiation Research 150(2): 204-211, 1998 (Aug).
  80. Okunieff P, Wang X, Li M, Sabet H, Huang K, Grieg J, Williams J, Rubin P, Ding I. Chronic radiation bone toxicity is associated with decreased perfusion without elevation of ciculating or soft tissue TGF beta or TNF alpha. Adv in Exptl Med & Biol 454: 325-333, 1998.
  81. Okunieff P, Mester M, Wang J, Maddox T, Gong X, Tang D, Coffee M, Ding I. In vivo radioactive effects of angiogenic growth factors on the small bowel of C3H mice. Radiat Res 150: 204-211, 1998.
  82. Epstein A, Lebovics R, Van Waes C, Smith J, Okunieff P, Cook J. Intravenous delivery of 5'-iododeoxyuridine during hyperfractionated radiotherapy for locally advanced head and neck cancer: Results of a pilot study. Laryngosocope 108: 1090-1094, 1998.
  83. Wang X, Ding I, Xie H, Wu T, Wersto N, Huang K, Okunieff P. Hyperbaric oxygen and basic fibroblast growth factor promote growth of irradiated bone. Int J Radiat Oncol Biol Phys. 40: 189-196, 1998.
  84. Danforth D, Zujewski J, O'Shaughnessy J, Riseberg D, Steinberg S, McAtee N, Noone M, Chow C, Chaudhry U, Lippman M, Jacobson J, Okunieff P, Cowan K. Selection of local therapy after neoadjuvant chemotherapy in patients with stage IIIA, B breast cancer. Annals of Surgical Oncology 5: 150-158, 1998.
  85. Greig J, Harrington F, Miller R, Wersto N, Okunieff P. Head and neck compensation for total body irradiation using opposed laterals. Medical Dosimetry. 23: 11-14, 1998.
  86. Okunieff P, Wang X, Rubin P, Finkelstein J, Constine L. Radiation-induced changes in bone perfusion and angiogenesis. Int J Radiat Oncol Biol Phys 42: 885-889, 1998.
  87. Okunieff P, Wang X, Li M, Sabet H, Huang K, Grieg J, Williams J, Rubin P, Ding I. Chronic radiation bone toxicity is associated with decreased perfusion without elevation of circulating or soft tissue TGFbeta or TNFalpha. Adv Exp Med Biol 454: 325-333, 1998.
  88. Okunieff P, Barrett A, Phang S, Li A, Constine L, Williams J, Rubin P, Wang X, Wu T, Chen Y, Ding I. Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation. Bone Marrow Transplantation. 23: 1117-1121, 1999.
  89. Fitzek M, Thornton A, Rabinov J, Lev M, Pardo F, Munzenrider J, Okunieff P, Bussiere M, Braun I, Hochberg F, Hedley-Whyte E, Liebsch N, Harsh G. Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial. J Neurosurg 91: 251-260, 1999.
  90. Rubin P, Williams J, Schell M, Okunieff P. Radiation inhibition of arterial restenosis - a new frontier. Acta Oncologica 38: 407-424, 1999.
  91. Williams JP; Rubin P; Soni A; Hernady E; Schell M; Green R; Illig K; Pomerantz R; and Okunieff P. Comparability of the external vs internal location of radiation in inhibiting neointimal hyperplasia. Journal of Cardiovascular Radiation Medicine 1:1, 55-63, 1999.
  92. Williams J, Rubin P, Soni A, Hernady E, Schell M, Green R, Illig K, Pomerantz P, Okunieff P. Comparability of the external vs. internal location of radiation in inhibiting neointimal hyperplasia. Cardiovasc Radiat Med 1: 55-63, 1999.
  93. Illig K, Soni A, Williams J, Shortell C, Okunieff P, Schell M, Rubin P, Green R. Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. J Amer Coll Surg 190: 364-370, 2000.
  94. Yu Y, Zhang J, Cheng G, Schell M, Okunieff P. Multi-objective optimization in radiotherapy: applications to stereotactic radiosurgery and prostate brachytherapy. Artificial Intelligence in Medicine 19: 39-51, 2000.
  95. Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys 49: 641-648, 2001.
  96. Illig K, Williams J, Lyden S, Hernady E, Soni A, Davies M, Schell M, Okunieff P, Rubin P, Green R. External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass: preliminary results. Annals of Vasc Surg 15(5): 533-538, 2001.
  97. Chen Y, Taghian A, Rosenberg A, O'Connell J, Okunieff P, Suit H. Predictive value of histologic tumor necrosis after radiation. Int J Cancer (Radiat Oncol Invest): 96, 334-340, 2001.
  98. Ding I, Sun J, Fenton B, Liu W, Kimsely P, Okunieff P, Min W. Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in Mca-4 murine mammary carcinomas. Cancer Research. 61(2): 526-31, 2001 (Jan).
  99. Abraham E, Shrivastav B, Salikhova A, Sterling K, Johnston N, Guidotti G, Scala S, Litman T, Chan K, Arceci R, Steiglitz K, Herscher L, Okunieff P. Cellular and biophysical evidence for interactions between adenosine triphosphate and P-glycoprotein substrates: functional implications for adenosine triphosphate/drug cotransport in P-glycoprotein overexpressing tumor cells and in P-glycoprotein low-level expressing erythrocytes. Blood Cells Mol Dis 27(1): 181-200, 2001 (Jan-Feb).
  100. Abraham E, Sterling K, Kim R, Salikhova A, Huffman H, Crockett M, Johnston N, Parker H, Boyle W, Hartov A, Demidenko E, Efird J, Kahn J, Grubman S, Jefferson D, Robson S, Thakar J, Lorico A, Rappa G, Sartorelli A, Okunieff P. Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis. Blood Cells Mol Dis 27(1): 165-180, 2001 (Jan-Feb).
  101. Pateder D, Eliseev R, O'Keefe R, Schwarz E, Okunieff P, Constine L, Puzas J, Rosier R. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiat Res 155(6): 847-857, 2001 (Jun).
  102. Fenton B, Beauchamp B, Paoni S, Okunieff P, Ding I. Characterization of the effects of antiangiogenic agents on tumor pathophysiology. Am J Clin Oncol 24(5): 453-7, 2001 (Oct).
  103. Hammond M, Ang K, Byhardt R, Campbell B, Chapman J, Eisenberg B, Greven K, Harris J, Hoffman J, Lange C, McCormick B, Mehta M, Sandler H, Trotti A, Willett C, Wolfson A, Furness A, Jensen T, Grignon D, Okunieff P. Radiation Therapy Oncology Group Research Plan 2002-2006: Tumor Utilization Committee. Int J Radiat Oncol Biol Phys 51(3 Suppl 2): 103-9, 2001.
  104. Okunieff P, Hammond E, Grignon D, Langer C, Pajak T, Ang K, Bruner D, Travis E, Greven K, Guha A, Moulder J, Pollack A, Scarantino C, Sneige N, Watson J, Amin M, Bondy M, Chakravarti A, Chapman J, Dicker A, Harris J, Koch W, Komaki R, Lange C, McBride W, Mitchell J, Milas L, Movsas B, Pandya K, Pienta K, Regine W, Ritter M, Rubin P, Safran H, Sauter E, Schell M, Stevens C, Trotti A, Vikram B. Radiation Therapy Oncology Group Research Plan 2002-2006: Translational Research Program. Int J Radiat Oncol Biol Phys 51(3 Suppl 2): 75-87, 2001.
  105. Watkins Bruner D, Berk L, Bondy M, Kachnic L, Konski A, Layne E, Lee W, Choucair A, Movsas B, Okunieff P, Roach M, Scott C, Vijayakumar S, Wenzel L. Radiation Therapy Oncology Group Research Plan 2002-2006: Outcomes Committee. Int J Radiat Oncol Biol Phys 51(3 Suppl 2): 66-74, 2001.
  106. Okunieff P, Li M, Liu W, Sun J, Fenton B, Zhang L, Ding I. Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma. Am J Clin Oncol 24(5): 491-5, 2001 (Oct).
  107. Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein J, Rubin P, Okunieff P. Radiation pneumonitis and early circulatory cytokine markers. Sem Rad Onc 12:1 Suppl 1 (January), 26-33, 2002.
  108. O'Dell W, Schell M, Reynolds D, Okunieff P. Dose broadening due to target position variability during fractionated breath-held radiation therapy. Medical Physics, 29(7): 1430-37, 2002 (July).
  109. Soni A, Illig K, Sternbach Y, Anthony P, Jacob P, Reddy G, Storey J, Gerety R, Williams J, Schell M, Waldman D, Rubin P, Green R, Okunieff P. Benefits of external beam irradiation for peripheral arterial bypass: preliminary report on a phase I study. Int J Radiat Oncol Biol Phys 15: 54(4): 1174-9, 2002 (Nov).
  110. Johnston C, Williams J, Okunieff P, Finkelstein J. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res 157(3): 256-65, 2002 (Mar).
  111. Pateder D, Sheu T, O'Keefe R, Puzas J, Schwarz E, Constine L, Okunieff P, Rosier R. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiat Res 157(1): 62-8, 2002 (Jan).
  112. Ding I, Liu W, Sun J, Fenton B, Okunieff P. Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas. Comp Biochem Physiol A Mol Integr Physiol 132(1): 17-25, 2002 (May).
  113. Chapman J, Bradley J, Eary J, Haubner R, Larson S, Michalski J, Okunieff P, Strauss H, Ung Y, Welch M. Molecular (functional) imaging fro radiotherapy applications: an RTOG Symposium. Int J Rad Onc Biol Phys 55:2, 294-301, 2003.
  114. Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 13(3): 182-8, 2003 (Jul).
  115. Biswas T, Sandhu A, Singh D, Schell M, Maciunas R, Bakos R, Muhs A, Okunieff P. Low-dose radiosurgery for benign intracranial lesions. Am J Clin Oncol 26(4): 325-31, 2003 (Aug).
  116. Liang L, Hu D, Liu W, Williams JP, Okunieff P, Ding I. Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA _expression in irradiated skin but not in irradiated mammary tumor. Am J Clin Oncol 26(4): S114-21, 2003 (Aug).
  117. Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. Am J Clin Oncol 26(4): S103-9, 2003 (Aug).
  118. Chen Y, Pandya K, Keng PC, Johnstone D, Li J, Lee YJ, Smudzin T, Okunieff P. Phase I/II Clinical Study of Pulsed Paclitaxel Radiosensitization for Thoracic Malignancy: A Therapeutic Approachon the Basis of Preclinical Research of Human Cancer Cell Lines. Clin Cancer Res 9(3):969-75, 2003 (Mar).
  119. Liu H, Yu Y, Schell M, O'Dell W, Ruo R, Okunieff P. Optimal marker placement in photogrammetry patient positioning system. Med Phys 30(2): 103-10, 2003 (Feb).
  120. Okunieff P, Ding I, Vaupel P, Hockel M. Evidence for and against hypoxia as the primary cause of tumor aggressiveness. Adv Exp Med Biol 510: 69-75, 2003.
  121. Okunieff P, Meyn R, Teicher B, Thomas C, Gaspar L, Raben D, Giri S, Lavey R, Turrisi A, Swanson G, Smalley S. Report from the Radiation Oncology Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2003. Amer J Clin Onc 26(5): 522-529, 2003 (Oct).
  122. Chapman J, Bradley J, Eary J, Haubner R, Larson S, Michalski J, Okunieff P, Strauss H, Ung Y, Welch M. Molecular (functional) imaging for radiotherapy applications: an RTOG Symposium. IJROBP 55(2): 294-301, 2003.
  123. Chen Y, Okunieff P, Ahrendt S. Translational research in lung cancer. Sem Surg Onc 21: 205-219, 2003.

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Last Modified: Dec. 2005