Louis S. Constine, M.D.

Clinical Specialty

Research Overview

Selected Honors

Predoctoral Fellowship Awards

1970. National Institute of Health Fellowship, Stanford Medical Center; Pediatric Psychiatry
1971. United Cerebral Palsy Foundation Fellowship Award, Guy's Hospital & Great Ormond Street Hospital for Sick Children, England; Neurodevelopment

Postdoctoral Fellowship Awards

1. ACS Education Grant, Childrens Orthopaedic Hospital; Pediatric Hematology/Oncology
2. NCI Cancer Center Grant, Stanford Medical Center; Radiation Therapy
3. National Cancer Institute Education Grant, Stanford Medical Center; Radiation Therapy
4. American Cancer Society Fellowship, Stanford Medical Center; Radiation Therapy
5. American Cancer Society Junior Faculty Clinical Fellowship #703A

Honors

1969. Beta Kappa
1969. Stanford University graduation "with distinction"
1983. Teddy Award, Camp Good Days and Special Times
1984. American Cancer Society Junior Faculty Fellowship Award
1997. Universtiy of Rochester Department of Radiation Oncology Teaching Award
2001. Jacob Gitleman Award, Cancer Action
2001. Philip Rubin-Mayer Michell Teaching Award, University of Rochester Department of Radiation Oncology

Education

• 1973-1975 H. C. Moffitt Hospital, University of California, Internship/Residency in Pediatrics
• 1975-1976 Stanford University Medical Center, Senior Residency in Pediatrics
• 1976-1978 Children's Orthopaedic Hospital, University of Washington Medical Center, Fellowship in Pediatric Hematology/Oncology
• 1978-1981 Stanford University Medical Center, Residency in Radiation Oncology
• 1969 Stanford University, Stanford, California; B.A., History
• 1973 The Johns Hopkins University School of Medicine, Baltimore, Maryland, M.D.

Academic Appointments

• 1981-1986 Strong Memorial Hospital, Assistant Radiation Oncologist
• 1987 Strong Memorial Hospital, Surgical Radiation Oncologist-with Admitting Privileges
• 1987 Strong Memorial Hospital, Associate Radiation Oncologist
• 1996 Strong Memorial Hospital, Radiation Oncologist

Hospital Appointments

• 7/1/81-6/30/87 University of Rochester School of Medicine & Dentistry, Assistant Professor, Radiation Oncology (Primary Appointment)
• 7/1/81-6/30/87 University of Rochester School of Medicine & Dentistry, Assistant Professor, Pediatrics (Secondary Appointment)
• 7/1/87-9/30/96 University of Rochester School of Medicine & Dentistry, Associate Professor, Radiation Oncology (Primary Appointment)
• 7/1/87-9/30/96 University of Rochester School of Medicine & Dentistry, Associate Professor, Pediatrics (Secondary Appointment)
• 10/1/96- University of Rochester School of Medicine & Dentistry, Professor of Radiation Oncology (Primary Appointment)
• 10/1/96- University of Rochester School of Medicine & Dentistry, Professor of Pediatrics (Secondary Appointment)

Publications

1. Silverman, S., Constine, L., Harvey, W. and Grahame, R. Survey of joint mobility and in vivo skin elasticity in London school children. Ann. Rheum. Dis. 34:177-180, 1975.
2. Constine, L. and McDougall, I.R. Radiation therapy for Hodgkin's disease followed by hypothyroidism and then Grave's hyperthyroidism. Clin. Nucl. Med. 7:69-70, 1982.
3. Coleman, C., Lee, W., Constine, L. and Brown, J. The development of an oral prodrug SR-2545 of the 2-nitromidazole radiosensitizer SR-2508. Int. J. Rad. Onc. Biol. Phys. 8:431-434, 1982.
4. Constine, L.S., Donaldson, S.S., McDougall, I.R., Cox, R.S., Link, M.P. and Kaplan, H.S. Thyroid dysfunction after radiotherapy in children with Hodgkin's disease. Cancer 53:878-883, 1984.
5. Scarantino, C.W., Rubin, P. and Constine, L.S. The paradoxes in patterns and mechanism of bone marrow regeneration after irradiation: 1. Different volumes and doses. Radiotherapy and Oncology 2(3):215-225, 1984.
6. Rubin, P., Constine, L.S. and Scarantino, C.W. The paradoxes in patterns and mechanism of bone marrow regeneration after irradiation: 2. Total body irradiation. Radiotherapy and Oncology 2(3):227-234, 1984.
7. Keng, P.C., Rubin, P., Constine, L.S., Frantz, C., Nakissa, N. and Gregory, P.K. Characterization of the biophysical properties of human tumor and bone marrow cells as a preliminary step to the use of centrifugal elutriation in autologous bone marrow transplantation. Int. J. Rad. Onc. Biol. Phys. 10:1913-1922, 1984.
8. Rubin, P., Salazar, O., Zagars, G., Constine, L.S., Keys, H., Poulter, C.A. and Van Ess, J.D. Systemic hemibody irradiation for overt and occult metastases. Cancer 55:2210-2221, 1985.
9. Frantz, C.N., Duerst, R.E., Ryan, D.H., Gelsomino, N.L., Constine, L.S. and Gregory, P.K. Anti-neuroblastoma monoclonal antibodies which do not bind to bone marrow cells. Prog. Clin. Biol. Res. 175:487-499, 1985.
10. Nakissa, N., Constine, L.S., Rubin, P. and Strohl, R. Birth defects in three common pediatric malignancies; Wilm's tumor, neuroblastoma and Ewing's sarcoma. Oncology 42:358-363, 1985.
11. Constine, L.S., Zagars, G., Rubin, P. and Kligerman, M. Protection by WR-2721 of human bone marrow function following irradiation. Int. J. Rad. Onc. Biol. Phys. 12:1505-1508, 1986.
12. Frantz, C.N., Duerst, R.E., Ryan, D.H., Constine, L.S., Gelsomino, N., Rust, L. and Gregory, P. A monoclonal anti-neuroblastoma antibody that discriminates between human nonhematopoietic and hematopoietic cell types. Hybridoma 5:297- 306, 1986.
13. Constine, L.S., Rubin, P. and Gregory, P.K. The differential protection by WR-2721 of skin versus growing cartilage following irradiation in weanling rats. Radiation Research 110:61-71, 1987.
14. Constine, L.S., Rubin, P., Woolf, P.D., Doane, K. and Lush, C.M. Hyperprolactinemia and hypothyroidism following cytotoxic therapy for central nervous system malignancies. J. Clin. Oncol. 5(11): 1841-1851, 1987.
15. Rubin, P., Constine, L.S. and Van Ess, J. Late effects toxicity scoring, a tale of two modalities interacting. NCI Monograph 6: 9-19, 1988.
16. Constine, L.S., Konski, A., Ekholm, S., McDonald, S. and Rubin, P. Adverse effects of brain irradiation correlated with MR and CT imaging. Int. J. Rad. Onc. Biol. Phys. 15:319-330, 1988.
17. Rubin, P., Whitaker, John N., Ceckler, Toni L., Nelson, Diana, Gregory, Philip K., Baggs, Raymond B., Constine, Louis S., and Herman, Paula K. Myelin basic protein and magnetic resonance imaging for diagnosing radiation myelopathy. Int. J. Rad. Onc. Biol. Phys. 15:1371-1381, 1988.
18. Constine, Louis S., Randall, Stephen H., Rubin, Philip, and McDonald, Joseph. Craniopharyngiomas: Fluctuation in cyst size following surgery and radiation therapy. Neurosurgery 24(1):53-59, 1989.
19. Bleyer, W.A., Fallavollita, J., Robison, L., Balsom, W., Meadows, A., Heyn, R., Sitarz, A., Ortega, J., Miller, D., Constine, L., Nesbit, M. Sather, H., and Hammond, D. Influence of age, sex and concurrent intrathecal methotrexate therapy on intellectual function after cranial irradiation during childhood: a report from the Children's Cancer Study Group. Pediat. Hemat. Oncol. 7:329-338, 1990.
20. Fryer, C.J., Hutchinson, R.J., Krailo, M., Collins, R.D., Constine, L.S., Hays, D.M., Heller, R.M., Davis, P.C., Nachman, J., O'Brien, R.T., O'Neill, K., Trigg, M.E., and Hammond, G.D. Efficacy and toxicity of twelve courses of ABVD followed by low dose regional radiation in advanced Hodgkin's disease in children: a report from the Children's Cancer Study Group. J. Clin. Oncol. 8(12):1971-1980, 1990.
21. Savage, D.E., Constine, L.S., Schwartz, R.G., and Rubin, P. Radiation effects on left ventricular function and myocardial perfusion in long term survivors of Hodgkin's disease. Int. J. Radiat. Oncol. Biol. 19(3):721-727, 1990.
22. Constine, L.S., Harwell, S., Keng, P., Siemann, D. and Rubin, P. Interleukin 1 alpha stimulates hemopoiesis but not tumor cell proliferation and protects mice from lethal total body irradiation. Int. J. Rad. Onc. Biol. Phys. 20:447-456, 1991.
23. Constine, Louis S. Late Effects of Radiation Therapy. Pediatrician 18:37-48, 1991.
24. Hays, D.M., Fryer, C.J., Pringle, K.C., Collins, R., Hutchinson, R., O'Neill, J., Constine, L.S., Heller, R.M., Davis, P.C., Nachman, J., O'Brien, R.T., Trigg, M.E., Krailo, M.D., and Hammond G.D. An Evaluation of abdominal staging procedures performed in pediatric patients with advanced Hodgkin's disease. A report from the Children's Cancer Study Group. J. Pediat. Surg., 27:1175-1180, 1992.
25. Karasek, K., Constine, L.S., and Rosier, R. Sarcoma therapy: Functional outcome and relationship to treatment parameters. Int. J. Rad. Oncol. Biol. and Phys. 24:651-656, 1992.
26. Constine, L.S. and Donaldson, S. Pediatric radiation oncology: Subspecialty training? Int. J. Rad. Oncol. Biol. Phys., 24:881-884, 1992.
27. Constine L.S. Basic concepts of chemotherapy-radiotherapy interactions. in Busch, D. B. Radiation and chemotherapy injury: pathophysiology, diagnosis, and treatment. Crit. Rev. Oncol/Hemat. 15:54, 1993.
28. Constine L.S. Effects of radiation and chemotherapy on bone marrow. in Busch, D. B. Radiation and chemotherapy injury: pathophysiology, diagnosis, and treatment. Crit. Rev. Oncol/Hemat. 15:59, 1993.
29. Constine L.S. Pediatric radiation and chemotherapy injury. in Busch, D. B. Radiation and chemotherapy injury: pathophysiology, diagnosis, and treatment. Crit. Rev. Oncol/Hemat. 15:60, 1993.
30. Nelson, D.F., Curran, Jr., W.J., Scott, C., Nelson, J.S., Weinstein, A.S., Ahmad, K., Constine, L.S., Murray, K., Powlis, W.D., Mohiuddin, M., and Fischbach, J. Hyperfractionated radiation therapy and Bis-Chlorethyl Nitrosourea in the treatment of malignant glioma - possible advantage observed at 72.0 Gy, in 1.2 Gy B.I.D. fractions: report of the Radiation Therapy Oncology Group Protocol 8302. Int. J. Rad. Onc. Biol. Phys. 25:193-207, 1993.
31. Rapoport, A., Rowe, J., Kouides, P., Duerst, R., Abboud, C., Liesveld, J., Packman, C., Eberly, S., Sherman, M., Tanner, M., Constine, L., DiPersio, J. One hundred autotransplants for relapsed or refractory Hodgkin's disease and lymphoma: value of pre-transplant disease status for predicting outcome. J. Clin. Oncol. 11:2351-2361, 1993.
32. Schwartz, C., Hobbie, W., Truesdell, S., Constine, L., Clark E. Corrected QT interval prolongation in anthracyline-treated survivors of childhood cancer. J. Clin. Oncol. 11:1906-1910, 1993.
33. Constine, L.S., Woolf, P.D., Cann, D., Mick, G., McCormick, K., Raubertas, R.F., Rubin, P. Hypothalamic-pituitary dysfunction after radiation for brain tumors. New Engl. J. Med., 328:87-94, 1993.
34. Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J., Deeg, H. Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy. Int. J. Rad. Onc. Biol. Phys. 31(5): 1319-1340, 1995.
35. Stewart, J., Fajardo, L., Gillette, S., Constine, L. Radiation injury to the heart. Int. J. Rad. Onc. Biol. Phys. 31(5): 1205-1212, 1995.
36. Sklar, C., Constine, L. Chronic neuroendocrinological sequelae of radiation therapy. Int. J. Rad. Onc. Biol. Phys. 31(5): 1113-1122, 1995.
37. Hancock, S.L., McDougall, I.R., Constine, L.S. Thyroid abnormalities after therapeutic external radiation. Int. J. Rad. Onc. Biol. Phys. 31(5): 1165-1170, 1995.
38. Rubin, P., Constine, L., Fajardo, L., Phillips, T., Wasserman, T., Bartelink, H., Denekamp, J., Horiot, J-C., Mornex, F., Overgaard, J., Pavy, J-J. Introduction: Joint Statement of Mission by RTOG/EORTC Working Groups. Int. J. Rad. Onc. Biol. Phys. 31(5): 1041-1043, 1995.
39. Rubin, P., Constine, L., Fajardo, L., Phillips, T., Wasserman, T. RTOG Late Effects Working Group - Overview: Late Effects of Normal Tissues (LENT) Scoring System. Int. J. Rad. Onc. Biol. Phys. 31(5): 1037-1041, 1995.
40. Rapoport, A., DiPersio, J., Martin, B., Duerst, R., Kouides, P., Liesveld, J., Abboud, C., Eberly, S., Sherman, M., Tanner, M., Constine, L., Rowe, J. Patients > age 40 undergoing auto- or allo-BMT have regimen-related mortality rates and event-free survivals comparable to patients < age 40. Bone Marrow Transplantation, 15:523-530, 1995.
41. Rubin, P., Constine, L., Fajardo, L., Phillips, T., Wasserman, T. RTOG Late Effects Working Group -- Overview: Late Effects of Normal Tissues (LENT) Scoring System. Radiotherapy and Oncology, 35:9-11, 1995 [note: this is republication of #39].
42. McDonald, S., Rubin, P. Constine, L., Williams, J., Smudzin, T. Biochemical markers as predictors for pulmonary effects of radiation. Rad. Onc. Invest.,3:56-63, 1995.
43. Simpson, J., Scott, C., Rotman, M., Curran, W., Constine, L., Fischbach, A., Asbell, S. Race and prognosis of brain tumor patients entering multicenter clinical trials -- a report from the Radiation Therapy Oncology Group. Am. J. Clin. Oncol., 19:114-120, 1996.
44. King, V., Constine, L., Clark, D., Schwartz, R., Muhs, A., Rubin, P. Symptomatic coronary artery disease after mantle irradiation for Hodgkin's disease. Int. J. Rad. Onc. Biol. Phys., 36(4): 881-890, 1996.
45. Rapoport, A., Lifton, R., Constine, L., Duerst, R., Abboud, C., Liesveld, J., Packman, C., Eberly, S., Raubertas, R. Martin, B., Flesher, W., Kouides, P., DiPersio, J., Rowe, J. Autotransplantation for Relapsed or Refractory Non-Hodgkin's Lymphoma (NHL): Long-Term Follow-up and Analysis of Prognostic Factors. Bone Marrow Transplant. 19:883-890, 1997.
46. Karayalcin, G., Behm, F., Gieser, P., Kung, F., Weiner, M., Tebbi, C., Ferree, C., Marcus, R., Constine, L., Mendenhall, N., Chauvenet, A.., Murphy, S. Lymphocyte predominant Hodgkin's Disease: clinico-pathologic features and results of treatment: The Pediatric Oncology Group experience. Medical & Pediatric Oncology. 29:519-525, 1997.
47. Constine, L., Schwartz, R., King, V., Savage, D., Muhs, A., Rubin, P. Cardiac function, perfusion and morbidity in irradiated long-term survivors of Hodgkin's disease. Int. J. Rad. Onc. Biol. Phys.,39:897-906, 1997.
48. Bieri, S., Sklar, C.A., Constine, L.S., Bernier, J. Effets tardifs de la radiotherapie sur la sphere neuro-endocrine. Cancer/Radiotherapie, 1:706-16, 1997.
49. Hinkle, Al., Truesdale, S., Proukou, C., Constine, L. Cardiotoxicity related to cancer therapy. Progress in Pediatric Cardiology,8:145-155, 1998.
50. Rapoport AP, Constine LS, Packman CH, Rosier RN, O'Keefe R, Hicks D, Rubin S, Rowe J. Treatment of multifocal lymphoma of bone with intensified promace-cytobom chemotherapy and involved field radiotherapy. Amer J Hemat, 58:1-7, 1998.
51. Lancet J, Rapoport A, Brasacchio R, Eberly S, Raubertas R, Linder T, Muhs A, Duerst R, Abboud C, Packman C, DiPersio J, Constine L, Rowe J, Liesveld L. Autotransplantation for relapsed or refractory Hodgkin's disease: long-term follow-up and analysis of prognostic factors. Bone Marrow Trans, 22:265-271, 1998.
52. Okunieff P, Wang X, Rubin P, Finkelstein J, Constine L, Ding I. Radiation-induced changes in bone perfusion and angiogenesis. Int J Radiat Oncol Biol Phys 42:885-89, 1998.
53. Korones D, Meyers S, Rubio A, Torres C, Constine L. A 4-year-old girl with a ventriculoperitoneal shunt metastasis of a central nervous system atypical teratoid/rhabdoid tumor. Med and Ped Oncol., 32:389-391, 1999.
54. Okunieff P, Barrett A, Phang S, Li A, Constine L, Williams J, Rubin P, Wang X, Wu T, Chen Y, Ding I. Circulating basic fibroblast growth factor declines during Cy/TBI bone marrow transplantation. Bone Marrow Transp. 23:1117-1121, 1999.
55. Liesveld J, Duerst R, Rapoport A, Constine L, Abboud C, Packman C, Wedow L, Zwetsch L, McKenna B, Linder T, Silberman W, Swift S, Rowe J, DiPersio J. Continuous infustion cyclosporine and nifedipine to day +100 with short methotrexate and steroids as GVHD prophylaxis in unrelated donor transplants. Bone Marrow Trans 24:511-516, 1999.
56. Sandhu, A., Constine, L, Muhs, A., Woolf, P. Subclinical thyroid disease after radiation therapy detected by technetium 99m scanning. Int. J. Rad. Onc. Biol. Phys. 48:181-188, 2000.
57. Wolkov H, Elman A, Hoppe R, Pistenmaa D, Mauch P, Constine L, Deming R, Dosoretz D, Prosnitz L, Yahalom J, Chauvenet A, Connors J, Glick J, Leibel S. Staging evaluation for patients with Hodgkin's disease. Radioloy 215(S): 1207-1223, 2000.
58. Constine L, Wolkov H, Yahalom J, Mauch P, Deming R, Dosoretz D, Elman A, Hoppe R, Pistenmaa D, Prosnitz L, Chauvenet A, Connors J, Glick J, Leibel S. Pediatric Hodgkin's disease. Radioloy 215(S): 1225-1256, 2000.
59. Prosnitz L, Connors J, Deming R, Yahalom J, Mauch P, Constine L, Dosoretz D, Elman A, Hoppe R, Pistenmaa D, Wolkov H, Chauvenet A, Glick J, Leibel S. Stage III and IV Hodgkin's disease treatment guidelines. Radioloy 215(S): 1257-1268, 2000.
60. Deming R, Constine L, Elman A, Hoppe R, Mauch P, Dosoretz D, Pistenmaa D, Prosnitz L, Wolkov H, Yahalom J, Chauvenet A, Connors J, Glick J, Leibel S. Follow-up of Hodgkin's disease. Radioloy 215(S): 1269-79, 2000.
61. Horan, J., Duerst, R., Liesveld, J., Zwetsch, L., Constine, L., Rapaport, A., Abboud, C., Packman, C., Rowe, J., DiPersio, J. Allogeneic bone marrow transplantation for children with hematological malignancies: cytoreduction with fractionated total body irradiation, high-dose etoposide and cyclophosphamide. Bone Marrow Trans. 25:489-494, 2000.
62. Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiat Res. 2001 Jun;155(6):847-57.
63. Pateder D, Sheu T, O'Keefe R, Puzas J, Schwarz E, Constine L, Okunieff P, Rosier R. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Rad Res 157:62-68, 2002.
64. Adams J, Hardenberg P, Constine L, Lipshultz S. Radiation-associated cardiovascular disease. Critical Reviews in Oncology/Hematology 45(1): 55-77, 2003.
65. Korones D, Padowski J, Factor B, Constine L. Do children with optic pathway tumors have an increased frequency of other central nervous system tumors? Neuro-Oncology; 5(2):116-120, 2003.
66. Adams J, Lipshultz J, Schwartz C, Fajardo L, Coen J, Constine L. Radiation Associated Cardiovascular Disease:Manifestations and Management. Sem Rad Onc 13(3):346-357, 2003.
67. Hinkle A, Proukou C, French C, Kozlowski A, Constine L, Lipsitz S, Miller T, Lipshultz S. A clinic-based comprehensive care model for studying late effects in long-term survivors of pediatric illnesses. Pediatrics 2004; 113(4s):1141-1145
68. Constine L, Lipschultz S. Heart of the matter: risk factors for premature cardiovascular disease in cancer survivors. Amer Soc Clin Oncol 2004 Educational Book. 2004: 418-424
69. Hudson M, Constine L. Risk-adapted therapy for pediatric patients with Hodgkin's disease, or tiptoeing along the efficacy-toxicity tightrope. . Amer Soc Clin Oncol 2004 Educational Book. 2004: 645-652
70. Landier W, Bhatia S, Eshelman D, Forte K, Sweeney T, Hester A, Darling J, Armstrong F, Blatt J, Constine L, Freeman C, Friedman D, Green D, Marina N, Meadows A, Neglia J, Oeffinger K, Robison L, Ruccione K, Sklar C, Hudson M. Development of risk-based guidelines for childhood cancer survivors: the Children's Oncology Group long-term follow-up guidelines. J Clin Onc in press

1. Chen, J., McCance S, O'Keefe R, Miller-Watelet L, Rosier R., Constine L. Bone density changes following radiotherapy for extremity sarcoms. Revisions in process for Int. J. Radiat. Oncol. Biol. Phys.
2. Brasacchio, R., Constine, L., Rapoport, A., Rowe, J., Liesveld, J., Muhs, A., Raubertas, R., Eberly, S., Rubin, P. "Dose Escalation" of consolidation, conformal radiation therapy following autologous bone marrow transplant for recurrent Hodgkin's disease and non-Hodgkin's lymphoma. Revisions in process for Int. J. Rad. Onc. Biol. Phys.
3. Liesveld, J., Constine, L., Martin, B., Harbol, A., Abboud, C., Rubin, P. Radiation-induced cytokine release from human bone marrow.
4. Sandhu, A., Constine, L., Muhs, A., Schwartz, C., Nelson, D., Rubin, P. Spinal growth in children irradiated to the craniospinal axis for brain tumors. Awaiting final revisions for submission to Int. J. Rad. Onc. Biol. Phys.
5. Yi S, Smith D, Constine L. Optic pathway resistance to radiation injury. In progress.
6. Constine LS, Tarbell N, Hudson M, Schwartz C, Sandhu A, Rubin P, Marcus R, Kun L, Mauch P, Mendenhall N. Are girls treated for Hodgkin's disease at a higher risk for non-breast second malignancies than boys? In progress.

1. Rubin, P., Constine, L.S., and Bennett, J. Hodgkin's disease: IIB or not to be - using irradiation alone or in combination with chemotherapy? That is the question! J. Clin. Onc. 4(4):455-457, 1986.
2. Kun, L., Constine, L.S. Medulloblastoma-caution regarding new treatment approaches. Int. J. Rad. Onc. Biol. Phys. 20:897-900, 1991.
3. Constine, L.S. What else don't we know about the late effects of radiation in patients with head and neck cancer? Int. J. Rad. Onc. Biol. Phys. 31:427-430.
4. Constine, L.S., Marcus, R., Halperin, E. The future of therapy for childhood rhabdomyosarcoma: clues from molecular biology. Int. J. Rad. Onc. Biol. Phys. 32:1245-1250, 1995.
5. Constine, L.S., Leibel, S.A., Beating the Odds The Washington Post, September 22, 1996.
6. Constine, L.S., Rapoport, A.P. Hodgkin's disease, bone marrow transplantation, and involved field radiation therapy: coming full circle from 1902 to 1996. Int. J. Rad. Onc. Biol. Phys. 36:253-255, 1996.
7. Constine, L.S. Should MOPP-ABVD alone be standard for childhood Hodgkin's? J. Clin. Oncol. 16:1235, 1998.
8. Constine, L.S., Schwartz, R. Response to "Cardiac Function and Morbidity in Long-Term Survivors of Hodgkin's disease. Int. J. Radiat. Oncol. Biol. Phys. 41:971, 1998.
9. Rubin, P., Constine, L.S. Response to "Predicting normal tissue response to radiotherapy (Editorial]. Int. J. Radiat. Oncol. Biol. Phys. 45:246-7, 1999.

1. Halperin, E., Kun, L., Constine, L., and Tarbell, N. Pediatric Radiation Oncology. Raven Press, New York, 1989, pp. 434.
2. Halperin, E., Constine, L., Tarbell, N., Kun, L. Pediatric Radiation Oncology. Raven Press, New York, 2nd edition, 1994, pp. 625.
3. Schwartz, C., Hobbie, W., Constine, L., Ruccione, K. (eds) Survivors of Childhood Cancer: Assessment and Management. Mosby-Year Book, St. Louis, 1994, pp 413.
4. Rubin, P., Constine, L., Fajardo, L., Phillips, T., Wasserman, T. [eds] Consensus Conference on Late Effects of Cancer Treatment. (Dedicated issue Int. J. Rad. Onc. Biol. Phys.) Pergamon Press, New York, 1995, 31(5): 1093-1367.
5. Halperin, E., Constine, L., Tarbell, N., Kun, L. Pediatric Radiation Oncology. Lippincott-Raven Publishers, Philadelphia, 3rd edition , 1999, pp. 606.
6. Halperin, E., Constine, L., Tarbell, N., Kun, L. Pediatric Radiation Oncology 2/E (Russian Edition). Meditsina Publishing House, 1999, pp. 748.
7. Halperin, E., Constine, L., Tarbell, N., Kun, L. Pediatric Radiation Oncology. Lippincott-Raven Publishers, Philadelphia, 4th edition, in press.
8. Schwartz, C., Hobbie, W., Constine, L., Ruccione, K. (eds) Survivors of Childhood Cancer: Assessment and Management. Springer-Verlag GmbH & Co.KG 2nd edition, under contract.