University of Rochester Medical Center Department of Radiation Oncology James P. Wilmot Cancer Center MedicineHighest
Information For:

Jacqueline P. Williams, Ph.D


Associate Research Professor
Department of Radiation Oncology
Ph.D, University of London, 1989
No image available Clinical Specialty
Research Overview
Selected Honors
Publications

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Clinical Specialty

Radiation Therapy

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Research Overview

Dr. Williams' research is concentrated in radiation biology

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Selected Honors

  • Casarett Award for research in 1999.
  • Rubin-Mitchell Teaching Award in 2003.


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Publications

  1. Rubin P, Gash DM, Hansen JT, Nelson DF, Williams JP. Disruption of the blood-brain barrier as the primary effect of CNS irradiation. Radiother Oncol 1994; 31: 51-60.
  2. McDonald S, Rubin P, Constine L, Williams J, Finkelstein J, Smudzin T. Biochemical markers as predictors for pulmonary effects of radiation. Radiat Oncol Invest 1995; 3: 56-63.
  3. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines post-irradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys 1995; 33: 99-110.
  4. Sarac T, Riggs P, Williams J, Feins R, Baggs R, Rubin P, Green R. The effects of low-dose radiation on neointimal hyperplasia. J Vasc Surg 1995; 22: 17-24.
  5. Johnston CJ, Piedboeuf B, Baggs R, Rubin P, Williams JP, Finkelstein JN. Early and persistent alterations in the _expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor beta: mRNA levels in fibrosis resistant and sensitive mice following thoracic irradiation. Radiat Res 1996; 145: 762-767.
  6. Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT. ICAM-1 induction in the mouse CNS following irradiation. Brain, Behavior, and Immunity 1997; 11: 273-285.
  7. Rubin P, Williams JP, Riggs PN, Bartos S, Sarac T, Pomerantz R, Castano J, Schell M, Green RM. Cellular and molecular mechanisms of radiation inhibition of restenosis. Part I: Role of the macrophage and platelet-derived growth factor. Int J Radiat Oncol Biol Phys 1998; 40: 929-941.
  8. Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP. CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol 1998; 89: 222-230.
  9. Okunieff P, Wang X, Li M, Sabet H, Huang K, Grieg JR, Williams J, Rubin P, Ding I. Chronic radiation bone toxicity is associated with decreased perfusion without elevation of circulating or soft tissue TGFbeta or TNFalpha. Adv Exp Med Biol 1998; 454: 325-333.
  10. Rubin P, Constine LS, Williams JP. Late effects of cancer treatment: Radiation and drug toxicity. In: Principles and Practice of Radiation Oncology, 3rd edition. Perez CA, Brady LW, editors. Philadelphia, PA, Lippincott-Raven, 1998. pp. 155-212.
  11. Rubin P, Finkelstein JN, Williams JP. Paradigm shifts in the radiation pathophysiology of late effects in normal tissues: molecular vs classic concepts. In: Current Radiation Oncology, volume 3. Tobias JS, Thomas PRM, eds. London, UK, Arnold, 1998. pp. 1-26.
  12. Rubin P, Soni A, Williams JP. The molecular and cellular biologic basis for the radiation treatment of benign proliferative diseases. Semin Radiat Oncol 1999; 9: 203-214.
  13. Williams JP, Rubin P, Soni A, Hernady E, Schell M, Green R, Illig K, Pomerantz P, Okunieff P. Comparability of the external vs. internal location of radiation in inhibiting neointimal hyperplasia. Cardiovasc Radiat Med 1999; 1: 55-63.
  14. Williams JP, Eagleton M, Hernady E, Schell M, Illig K, Green R, Rubin P. Effectiveness of fractionated external beam radiation in the inhibition of vascular restenosis. Cardiovasc Radiat Med 1999; 1: 257-264.
  15. Illig KA, Williams J, Soni A, Rubin P, Schell M, Green RM. Irradiation for lower extremity arterial occlusive disease. Cardiovasc Radiat Med 1999; 1: 288-296.
  16. Rubin P, Williams J, Schell M, Okunieff P. Radiation inhibition of arterial restenosis: A new frontier. Acta Oncol 1999; 38: 407-424.
  17. Rubin P, Soni A, Williams JP. The molecular and cellular basis for the radiation treatment of benign proliferative diseases. Semin Radiat Oncol 1999; 9: 203-214.
  18. Illig KA, Soni A, Williams JP, Shortell CA, Okunieff P, Schell M, Rubin P, Green RM. Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. J Am Coll Surg 2000; 190: 364-370.
  19. Chen Y, Rubin P, Williams J, Hernady E, Smudzin T, Okunieff P. Circulating IL-6 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys 2001; 49: 641-648.
  20. Illig KA, Williams JP, Lyden SP, Hernady E, Soni A, Davies MG, Schell M, Okunieff P, Rubin P, Green RM. External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass: preliminary results. Ann Vasc Surg 2001; 15: 533-538.
  21. Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res 2002; 157: 256-265.
  22. Chen Y, Williams J, Ding I, Hernady, E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol 2002; 12 (1 suppl 1): 26-33.
  23. Sandhu A, Williams J, Constine L. Late effects of radiation therapy. In Encyclopedia of Cancer, 2cnd edition. Elsevier Science (USA), Philadelphia, 2002. pp 7-19.
  24. Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, O'Banion MK. Cyclooxygenase-2 modulates brain inflammation-related gene _expression in central nervous system radiation injury. Mol Brain Res 2002; 104: 159-169.
  25. Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA. Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21Cip1/WAF1/Sdi1. Am J Pathol 2002; 161: 1383-1393.
  26. Ferland RJ, Williams JP, Gross RA, Applegate CD. The effects of brain irradiation-induced decreases in hippocampal mitotic activity on flurothyl-induced epileptogenesis in adult C57BL/6J mice. Exp Neurol 2003; 179: 71-82.
  27. Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003; 13: 182-188.
  28. Bentzen SM, Dorr W, Anscher MS. Denham JW, Hauer-Jensen M, Marks LB, Williams J. Normal tissue effects: Reporting and analysis. Semin Radiat Oncol 2003; 13: 189-202.
  29. Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin TS, Williams JP, Messing E, Okunieff P. Is there a favorable subset of patients with prostate cancer who develop oligometastases? Int J Radiat Oncol Biol Phys 2004; 58: 3-10.
  30. Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK. Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. Radiat Res 2004; 161: 153-160.
  31. Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects following whole lung irradiation in a murine model. Radiat Res 2004; 161: 560-567.