Bruce M Fenton, Ph.D

Clinical Specialty

Research Overview

• Tumor oxygenation, vascularization, and radiation response, principle investigator
• Effect of angiogenic growth factors on tumor growth, vscular function, and the development of hypoxic theraputic resistance, principle investigator
• Sono-contrast induced functional imaging and spectroscopy, co-investigator
• iDQC MR imaging of tumor pathophysiology, co-investigator

Publications

1. Fenton, BM, BW Zweifach, and DM Worthen. Quantitative morphometry of conjunctival microcirculation in diabetes mellitus. Microvasc Res 18: 153166, 1979.
2. Worthen, DM, BM Fenton, P Rosen, and B Zweifach. Morphometry of diabetic conjunctival blood vessels. Ophthalmology 88: 655-657, 1981
3. Fenton, BM and BW Zweifach. Microcirculatory model relating geometrical variation to changes in pressure and flow rate. Annals Biomed Eng 9: 303321, 1981.
4. Fenton, BM, GR Cokelet, and PL La Celle. Influence of wall surface on the flow of blood through endotheliallined glass tubes. Int J Microcirc: Clin Exp 1: 157162, 1982.
5. Fenton, BM, RT Carr, and GR Cokelet. Nonuniform red cell distribution in 20100 micron bifurcations. Microvasc Res 29: 103126, 1985.
6. Fenton, BM, DW Wilson, and GR Cokelet. Analysis of the effects of measured white blood cell entrance times on hemodynamics in a computer model of a microvascular bed. Pflugers Archiv 403: 396401, 1985.
7. Rofstad, EK, BM Fenton, and RM Sutherland. Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: Relationship to tumour volume, tumour pH, and fraction of radiobiologically hypoxic cells. Br J Cancer 57: 494502, 1988.
8. Rofstad, EK, P DeMuth, BM Fenton, and RM Sutherland. 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res 48:5440-5446, 1988.
9. Fenton, BM, EK Rofstad, and RM Sutherland. Cryospectrophotometric determination of tumor intravascular HbO2 saturations: Dependence on vascular geometry and tumor growth. J Natl Cancer Inst 80:1612-1619, 1988.
10. Rofstad, EK, P DeMuth, BM Fenton, TL Ceckler, and RM Sutherland. 31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia. Int J Radiat Oncol Biol Phys 16:919-923, 1989.
11. Mueller-Klieser, W, C Schaifer, S Walenta, EK Rofstad, BM Fenton, and RM Sutherland. Assessment of tumor energy and oxygenation status by bioluminescence, NMR spectroscopy, and cryospectrophotometry. Cancer Res 50:1681-1685, 1990.
12. Fenton, BM and TEJ Gayeski. Cryospectrophotometric determination of HbO2 saturation in microvessels. Am J Physiol 259:H1912-H1920, 1990.
13. Fenton, BM, R Raubertas, and RM Sutherland. Time-dependent effects of anesthetic agents on 31P-NMR high energy phosphates in KHT and RIF-1 fibrosarcomas. NMR in Biomedicine 4:137-141, 1991.
14. Fenton, BM and RM Sutherland. Effects of anaesthetic agent on 31P-NMR high-energy phosphates and regional distributions of intravascular oxyhaemoglobin saturations. Int J Radiat Biol 60:115-119, 1991.
15. Fenton, BM and RM Sutherland. Effect of flunarizine on micro-regional distributions of intravascular oxyhemoglobin saturations in RIF-1 and KHT sarcomas. Int J Radiat Oncol Biol Phys 22:447-450, 1991.
16. Fenton, BM and BW Way. Vascular morphometry of KHT and RIF1 murine sarcomas. Radiother Oncol 28:57-62, 1993.
17. Fenton, BM and DJ Boyce. Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration. Int J Radiat Oncol, Biol, Phys 29:459-462, 1994.
18. Fenton, BM and DW Siemann. Investigations of perfusion-limited hypoxia in the KHT sarcoma. Adv Exp Med Biol 361: 627-634, 1994.
19. Fenton, BM, R Raubertas, and DJ Boyce. Quantification of micro-regional heterogeneities in tumor oxygenation using intravascular HbO2 saturations. Radiat Res 141:49-56, 1995.
20. Kiani, MF and BM Fenton. Inherent cellular differences may explain the dissimilar survival of RIF1 and KHT tumor cells under aerobic and hypoxic conditions Int J Radiat Biol 67:449-452, 1995.
21. Fenton, BM, MF Kiani, and DW Siemann. Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int J Radiat Oncol, Biol, Phys 33:365-373, 1995.
22. Fenton, BM and DW Siemann. Are direct measures of tumor oxygenation reflective of changes in tumor radiosensitivity following oxygen manipulation? Acta Oncologica 34:307-311, 1995.
23. Fenton, BM. The effects of carbogen and nicotinamide on intravascular HbO2 saturations in SCCVII and KHT tumors. Br J Cancer 71:945-949, 1995.
24. Kiani, MF, BM Fenton, LA Sporn, and DW Siemann. Effects of ionizing radiation on the adhesive interaction of human tumor and endothelial cells in vivo. Clin Expt Metast, 15:12-18, 1997.
25. Fenton, BM. Effects of carbogen plus fractionated irradiation on KHT tumor oxygenation. Radiother Oncol, 44:183-190, 1997.
26. Fenton, BM, SF Paoni, CJ Koch, and EM Lord. Image analysis of the effects of irradiation on tumor oxygenation and vascular structure. Annals Biomed Eng 25: S-13, 1997
27. Lee, J, BM Fenton, CJ Koch, JG Frelinger, and EM Lord. Interleukin-2 expression by tumor cells alters both the immune response and the tumor microenvironment. Cancer Res 58:1478-1485, 1998.
28. Fenton, BM, SF Paoni, CJ Koch, and EM Lord. Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia, Adv Expt Med Biol 454: 619-628, 1998.
29. Fenton, BM, SF Paoni, J Lee, CJ Koch, and EM Lord. Quantification of tumor vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements, Br J Cancer 79: 464-471, 1999.
30. Schell MC, DP Rosenzweig, KA Weaver, BM Fenton, P Rubin. Characterization of the dose perturbation by stents as a function of X-ray beam energy. Cardiovasc Radiat Med 1(2):154-159, 1999.
31. Fenton, BM, EM Lord, and SF Paoni. Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single and multi-fraction irradiation. Radiat Res 153: 75-83, 2000.
32. Lee, J, JP Moran, BM Fenton, CJ Koch, JG Frelinger, PC Keng, and EM Lord. Alteration of tumor response to radiation by interleukin-2 gene transfer. Br J Cancer 82: 937-944, 2000.
33. Conover, DL, BM Fenton, TH Foster, and EL Hull. An evaluation of near infrared spectroscopy and cryospectrophotometry estimates of hemoglobin oxygen saturation in a rodent mammary tumor model, Physics in Medicine and Biology 45(9):2685-2700), 2000.
34. Fenton, BM, EM Lord, and SF Paoni. Effects of irradiation on tumor intravascular oxygenation, vascular configuration, hypoxic development, and survival. Radiation Research 155(2):360-368, 2001.
35. Fenton, BM. Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models. Int J Radiat Oncol Biol Phys 49(3):799-808, 2001.
36. Fenton, BM, EM Lord, and SF Paoni. Intravascular HbO2 saturations, perfusion, and hypoxia in spontaneous and transplanted tumor models. Int J Cancer 93:693-698, 2001.
37. I Ding, JZ Sun, BM Fenton, WM Liu, P Kimsely, P Okunieff, and W Min, Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 mammary carcinomas, Cancer Res 61:526-531, 2001.
38. Fenton, BM, P Okunieff, and I Ding. Characterization of the effects of antiangiogenic agents on tumor pathophysiology, Am J Clin Oncol 24:453-457, 2001.
39. Okunieff, P, L Min, W Liu, J Sun, B Fenton, L Zhang and I Ding. KGFs radioprotect bowel and bone marrow but not KHT sarcoma, Am J Clin Oncol 24(5):491-495, 2001.
40. Fenton, BM, EM Lord, and SF Paoni. Effects of irradiation on tumor intravascular oxygenation, vascular configuration, hypoxic development, and survival, Radiation Research 155(2):360-368, 2001.
41. Fenton, BM, Paoni, SF, BK Beauchamp, and I Ding. Zonal image analysis of tumor vascular perfusion, hypoxia, and necrosis. Br J Cancer 86(11):1831-1836, 2002.
42. Fenton, BM, SF Paoni, BK Beauchamp, B Tran, L Liang, B Grimwood, and I Ding. Evaluation of microregional variations in tumor hypoxia following the administration of endostatin. Adv Expt Med Biol 510;19-24, 2003.
43. Fenton, BM, SF Paoni, BG Grimwood, and I Ding. Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas. Int J Radiat Oncol Biol Phys 57(4):1038-46, 2003.
44. Ding, I, P Okunieff, K Salnikow, W Liu, and B Fenton. A new intrinsic hypoxia marker in esophageal cancer. Adv Expt Med Biol 540:227-233, 2003.
45. Gerber, SA, JP Moran, JG Frelinger, JA Frelinger, BM Fenton, and EM Lord. Mechanism of IL-12 mediated alterations in tumor blood vessel morphology: analysis using whole tissue mounts. Br J Cancer 88 (9):1453-1461, 2003.
46. Guo, P, Q Fang, H-Q Tao, CA Schafer, BM Fenton, I Ding, B Hu, and S-Y Cheng. Overexpression of VEGF by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo. Cancer Res 63(15):4684-4691, 2003.
47. Fenton, BM and SF Paoni. Oxygenation and vascular perfusion in spontaneous and transplanted tumor models. Adv Exp Med Biol 530:165-176, 2003.
48. Okunieff, P, Fenton, BM, Zhang, L, Kern, FG, Wu, T, Greg, JR, and Ding, I. Fibroblast growth factors (FGFs) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density, Adv Expt Med Biol 530:593-601, 2003.
49. Ding, I, Liu, W, Sun, JZ, Paoni, SF, Hernady, E, Fenton, BM, and Okunieff, P. FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice, Adv Expt Med Biol 530:603-609, 2003.
50. Fenton, BM, SF Paoni, WM Liu, L Zhang, S-Y Cheng, and I Ding. Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumors. Br J Cancer 90(2):430-435, 2004.
51. Williams, JP, E Hernady, CJ Johnston, CM Reed, BM Fenton, P Okunieff, JN Finkelstein. Effect of Administration of Lovastatin on the Development of Late Pulmonary Effects Following Whole Lung Irradiation in a Murine Model. Radiation Research 161:460-467, 2004.
52. W Liu, Y Chen, W Wang, P Keng, J Finkelstein, D Hu, L Liang, M Guo, B Fenton, P Okunieff and I Ding. Combination of radiation and Celebrex^(TM) (celecoxib) reduce mammary and lung tumor growth, Am J Clin Oncol 26(4):S103-109, 2004.
53. Fenton, BM, SF Paoni, G Grimwood, and I Ding. Varied response of spontaneous tumors to anti-angiogenic agents. Adv Expt Med Biol (in press), 2004.
54. Fenton, BM, SF Paoni, and I Ding. Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors. Radiotherapy and Oncology (in press), 2004.
55. Fenton, BM, SF Paoni, and I Ding. Pathophysiological Effects of VEGF Receptor-2-Blocking Antibody plus Fractionated Radiotherapy on Murine Mammary Tumors. Cancer Res (in press), 2004.