Bruce M Fenton, Ph.D


Professor of Radiation Oncology, and Biomedical Engineering
Ph.D, University of California, San Diego, 1980
No image available

Contact Information:

University of Rochester Cancer Center
601 Elmwood Ave, Box 704
Rochester, NY 14642


Phone: (585) 275-7911
E-mail: bruce_fenton@urmc.rochester.edu

Biographical Sketch

Dr. Fenton recieved his BS in chemical engineering from Montana State University in Bozeman in 1972. He subsequently completed his masters program in 1975. He then went to the University of California at San Diego and recieved a Ph.D in Bioengineering. At the University of Rochester, from 1980 to 1983, he did postdoctoral work. He then was an instuctor in the department of Radiation Biology and Biophisics until 1987, then a sceintist at the Cancer Center, and then a Senior Instructor in the department of Radiation Oncology. In 1998 he moved from Assistant Professor of Oncology and of Biomedical Engineering to Associate Professor of Oncology and Biomedical Engineering. He was part of the Department of Defense Breast Cancer Program Study Section in 2003 and the NIH's Cancer Biomarkers Scientific Review Panel in 2004.

Clinical Specialty
Research Overview
Selected Honors
Education
Academic Appointments
Hospital Appointments
Major Committees
Publications
Radiation Oncology Home

_________________

Clinical Specialty

Radiological biomedical engineering

_________________

Research Overview

Recent project descriptions:
  • Tumor oxygenation, vascularization, and radiation response, principle investigator
  • Effect of angiogenic growth factors on tumor growth, vscular function, and the development of hypoxic theraputic resistance, principle investigator
  • Sono-contrast induced functional imaging and spectroscopy, co-investigator
  • iDQC MR imaging of tumor pathophysiology, co-investigator


_________________

Publications

  1. Fenton, BM, BW Zweifach, and DM Worthen. Quantitative morphometry of conjunctival microcirculation in diabetes mellitus. Microvasc Res 18: 153166, 1979.
  2. Worthen, DM, BM Fenton, P Rosen, and B Zweifach. Morphometry of diabetic conjunctival blood vessels. Ophthalmology 88: 655-657, 1981
  3. Fenton, BM and BW Zweifach. Microcirculatory model relating geometrical variation to changes in pressure and flow rate. Annals Biomed Eng 9: 303321, 1981.
  4. Fenton, BM, GR Cokelet, and PL La Celle. Influence of wall surface on the flow of blood through endotheliallined glass tubes. Int J Microcirc: Clin Exp 1: 157162, 1982.
  5. Fenton, BM, RT Carr, and GR Cokelet. Nonuniform red cell distribution in 20100 micron bifurcations. Microvasc Res 29: 103126, 1985.
  6. Fenton, BM, DW Wilson, and GR Cokelet. Analysis of the effects of measured white blood cell entrance times on hemodynamics in a computer model of a microvascular bed. Pflugers Archiv 403: 396401, 1985.
  7. Rofstad, EK, BM Fenton, and RM Sutherland. Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: Relationship to tumour volume, tumour pH, and fraction of radiobiologically hypoxic cells. Br J Cancer 57: 494502, 1988.
  8. Rofstad, EK, P DeMuth, BM Fenton, and RM Sutherland. 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res 48:5440-5446, 1988.
  9. Fenton, BM, EK Rofstad, and RM Sutherland. Cryospectrophotometric determination of tumor intravascular HbO2 saturations: Dependence on vascular geometry and tumor growth. J Natl Cancer Inst 80:1612-1619, 1988.
  10. Rofstad, EK, P DeMuth, BM Fenton, TL Ceckler, and RM Sutherland. 31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia. Int J Radiat Oncol Biol Phys 16:919-923, 1989.
  11. Mueller-Klieser, W, C Schaifer, S Walenta, EK Rofstad, BM Fenton, and RM Sutherland. Assessment of tumor energy and oxygenation status by bioluminescence, NMR spectroscopy, and cryospectrophotometry. Cancer Res 50:1681-1685, 1990.
  12. Fenton, BM and TEJ Gayeski. Cryospectrophotometric determination of HbO2 saturation in microvessels. Am J Physiol 259:H1912-H1920, 1990.
  13. Fenton, BM, R Raubertas, and RM Sutherland. Time-dependent effects of anesthetic agents on 31P-NMR high energy phosphates in KHT and RIF-1 fibrosarcomas. NMR in Biomedicine 4:137-141, 1991.
  14. Fenton, BM and RM Sutherland. Effects of anaesthetic agent on 31P-NMR high-energy phosphates and regional distributions of intravascular oxyhaemoglobin saturations. Int J Radiat Biol 60:115-119, 1991.
  15. Fenton, BM and RM Sutherland. Effect of flunarizine on micro-regional distributions of intravascular oxyhemoglobin saturations in RIF-1 and KHT sarcomas. Int J Radiat Oncol Biol Phys 22:447-450, 1991.
  16. Fenton, BM and BW Way. Vascular morphometry of KHT and RIF1 murine sarcomas. Radiother Oncol 28:57-62, 1993.
  17. Fenton, BM and DJ Boyce. Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration. Int J Radiat Oncol, Biol, Phys 29:459-462, 1994.
  18. Fenton, BM and DW Siemann. Investigations of perfusion-limited hypoxia in the KHT sarcoma. Adv Exp Med Biol 361: 627-634, 1994.
  19. Fenton, BM, R Raubertas, and DJ Boyce. Quantification of micro-regional heterogeneities in tumor oxygenation using intravascular HbO2 saturations. Radiat Res 141:49-56, 1995.
  20. Kiani, MF and BM Fenton. Inherent cellular differences may explain the dissimilar survival of RIF1 and KHT tumor cells under aerobic and hypoxic conditions Int J Radiat Biol 67:449-452, 1995.
  21. Fenton, BM, MF Kiani, and DW Siemann. Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int J Radiat Oncol, Biol, Phys 33:365-373, 1995.
  22. Fenton, BM and DW Siemann. Are direct measures of tumor oxygenation reflective of changes in tumor radiosensitivity following oxygen manipulation? Acta Oncologica 34:307-311, 1995.
  23. Fenton, BM. The effects of carbogen and nicotinamide on intravascular HbO2 saturations in SCCVII and KHT tumors. Br J Cancer 71:945-949, 1995.
  24. Kiani, MF, BM Fenton, LA Sporn, and DW Siemann. Effects of ionizing radiation on the adhesive interaction of human tumor and endothelial cells in vivo. Clin Expt Metast, 15:12-18, 1997.
  25. Fenton, BM. Effects of carbogen plus fractionated irradiation on KHT tumor oxygenation. Radiother Oncol, 44:183-190, 1997.
  26. Fenton, BM, SF Paoni, CJ Koch, and EM Lord. Image analysis of the effects of irradiation on tumor oxygenation and vascular structure. Annals Biomed Eng 25: S-13, 1997
  27. Lee, J, BM Fenton, CJ Koch, JG Frelinger, and EM Lord. Interleukin-2 expression by tumor cells alters both the immune response and the tumor microenvironment. Cancer Res 58:1478-1485, 1998.
  28. Fenton, BM, SF Paoni, CJ Koch, and EM Lord. Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia, Adv Expt Med Biol 454: 619-628, 1998.
  29. Fenton, BM, SF Paoni, J Lee, CJ Koch, and EM Lord. Quantification of tumor vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements, Br J Cancer 79: 464-471, 1999.
  30. Schell MC, DP Rosenzweig, KA Weaver, BM Fenton, P Rubin. Characterization of the dose perturbation by stents as a function of X-ray beam energy. Cardiovasc Radiat Med 1(2):154-159, 1999.
  31. Fenton, BM, EM Lord, and SF Paoni. Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single and multi-fraction irradiation. Radiat Res 153: 75-83, 2000.
  32. Lee, J, JP Moran, BM Fenton, CJ Koch, JG Frelinger, PC Keng, and EM Lord. Alteration of tumor response to radiation by interleukin-2 gene transfer. Br J Cancer 82: 937-944, 2000.
  33. Conover, DL, BM Fenton, TH Foster, and EL Hull. An evaluation of near infrared spectroscopy and cryospectrophotometry estimates of hemoglobin oxygen saturation in a rodent mammary tumor model, Physics in Medicine and Biology 45(9):2685-2700), 2000.
  34. Fenton, BM, EM Lord, and SF Paoni. Effects of irradiation on tumor intravascular oxygenation, vascular configuration, hypoxic development, and survival. Radiation Research 155(2):360-368, 2001.
  35. Fenton, BM. Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models. Int J Radiat Oncol Biol Phys 49(3):799-808, 2001.
  36. Fenton, BM, EM Lord, and SF Paoni. Intravascular HbO2 saturations, perfusion, and hypoxia in spontaneous and transplanted tumor models. Int J Cancer 93:693-698, 2001.
  37. I Ding, JZ Sun, BM Fenton, WM Liu, P Kimsely, P Okunieff, and W Min, Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 mammary carcinomas, Cancer Res 61:526-531, 2001.
  38. Fenton, BM, P Okunieff, and I Ding. Characterization of the effects of antiangiogenic agents on tumor pathophysiology, Am J Clin Oncol 24:453-457, 2001.
  39. Okunieff, P, L Min, W Liu, J Sun, B Fenton, L Zhang and I Ding. KGFs radioprotect bowel and bone marrow but not KHT sarcoma, Am J Clin Oncol 24(5):491-495, 2001.
  40. Fenton, BM, EM Lord, and SF Paoni. Effects of irradiation on tumor intravascular oxygenation, vascular configuration, hypoxic development, and survival, Radiation Research 155(2):360-368, 2001.
  41. Fenton, BM, Paoni, SF, BK Beauchamp, and I Ding. Zonal image analysis of tumor vascular perfusion, hypoxia, and necrosis. Br J Cancer 86(11):1831-1836, 2002.
  42. Fenton, BM, SF Paoni, BK Beauchamp, B Tran, L Liang, B Grimwood, and I Ding. Evaluation of microregional variations in tumor hypoxia following the administration of endostatin. Adv Expt Med Biol 510;19-24, 2003.
  43. Fenton, BM, SF Paoni, BG Grimwood, and I Ding. Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas. Int J Radiat Oncol Biol Phys 57(4):1038-46, 2003.
  44. Ding, I, P Okunieff, K Salnikow, W Liu, and B Fenton. A new intrinsic hypoxia marker in esophageal cancer. Adv Expt Med Biol 540:227-233, 2003.
  45. Gerber, SA, JP Moran, JG Frelinger, JA Frelinger, BM Fenton, and EM Lord. Mechanism of IL-12 mediated alterations in tumor blood vessel morphology: analysis using whole tissue mounts. Br J Cancer 88 (9):1453-1461, 2003.
  46. Guo, P, Q Fang, H-Q Tao, CA Schafer, BM Fenton, I Ding, B Hu, and S-Y Cheng. Overexpression of VEGF by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo. Cancer Res 63(15):4684-4691, 2003.
  47. Fenton, BM and SF Paoni. Oxygenation and vascular perfusion in spontaneous and transplanted tumor models. Adv Exp Med Biol 530:165-176, 2003.
  48. Okunieff, P, Fenton, BM, Zhang, L, Kern, FG, Wu, T, Greg, JR, and Ding, I. Fibroblast growth factors (FGFs) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density, Adv Expt Med Biol 530:593-601, 2003.
  49. Ding, I, Liu, W, Sun, JZ, Paoni, SF, Hernady, E, Fenton, BM, and Okunieff, P. FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice, Adv Expt Med Biol 530:603-609, 2003.
  50. Fenton, BM, SF Paoni, WM Liu, L Zhang, S-Y Cheng, and I Ding. Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumors. Br J Cancer 90(2):430-435, 2004.
  51. Williams, JP, E Hernady, CJ Johnston, CM Reed, BM Fenton, P Okunieff, JN Finkelstein. Effect of Administration of Lovastatin on the Development of Late Pulmonary Effects Following Whole Lung Irradiation in a Murine Model. Radiation Research 161:460-467, 2004.
  52. W Liu, Y Chen, W Wang, P Keng, J Finkelstein, D Hu, L Liang, M Guo, B Fenton, P Okunieff and I Ding. Combination of radiation and Celebrex^(TM) (celecoxib) reduce mammary and lung tumor growth, Am J Clin Oncol 26(4):S103-109, 2004.
  53. Fenton, BM, SF Paoni, G Grimwood, and I Ding. Varied response of spontaneous tumors to anti-angiogenic agents. Adv Expt Med Biol (in press), 2004.
  54. Fenton, BM, SF Paoni, and I Ding. Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors. Radiotherapy and Oncology (in press), 2004.
  55. Fenton, BM, SF Paoni, and I Ding. Pathophysiological Effects of VEGF Receptor-2-Blocking Antibody plus Fractionated Radiotherapy on Murine Mammary Tumors. Cancer Res (in press), 2004.

_________________

Back to the Radiation Oncology Home Page

Last Modified: Dec. 2005