CBARMFI Lectures

Dr. John Bennet
Professor Emeritus-James P. Wilmot Cancer Center, University of Rochester

Long-Term Effects from Hiroshima and Nagasaki

Thursday, June 1st• 8-9am
Cancer Center Conference Room (G-3111)

Dr. Bennett is Professor Emeritus of Medicine in the James P. Wilmot Cancer Center at the University of Rochester. He received his undergraduate degree from Harvard University and his medical degree from Boston University, both in Massachusetts. Postgraduate training included an internship at Massachusetts Memorial Hospital, a residency in medicine at Beth Israel Hospital, a fellowship in hematology at Bsoton City Hospital and Tufts University, and additional training at the NIH. He is a member of numerous professional societies, including the American Medical Association, American Association for the Advancement of Science, American Federation for Clinical Research, American Association for Cancer Research, American Society for Clinical Oncology, American Society of Hematology, and the International Society of Hematology. Dr. Bennett also serves as Chairman for the Myelodysplastic Syndromes Foundation. Dr. Bennett has contributed over 450 publications to the medical literature as well as several books, and he currently serves as Editor of Leukemia Research.

	CBARMFI Education & Training Core Special Lectures & Workshops 2005-2008
		Dr. Richard Britten, PhD Associate Professor of Radiation Oncology (Eastern Virginia Medical School) The use of proteomic profiling to assess individual susceptibility to radiation-induced cognitive impairment. Wednesday, December 19th • 12pm-1pm Pediatrics Conference Room (MRBX-3.11211) Dr. Britten is an Associate Professor in the Department of Radiation Oncology, and the Dept of Microbiology at EVMS. He also serves as an Adjunct Associate Professor in the Department of Physics at Hampton University. Dr. Britten received a PhD in Radiotherapy at the University of Leeds in England. Post-Docs in Liverpool and MD Anderson followed where he worked on the radiobiology of their neutron beams, and he continues to work on high LET radiobiology, holding grants from NASA to identify mechanisms of hadron-induced cognitive impairment, and from Varian to develop a biologically optimized treatment planning program for proton therapy. Dr. Britten is a Staff scientist at the Hampton University Proton Treatment Institute. His clinically applied research focuses on molecular triage for combined modality therapy, especially in cancer of the cervix, and predicting radiation-induced late reactions. Since arriving at EVMS in 2001, his research heavily involves proteomic analysis. He is the happy father of 5 children, and he plays and coaches rugby in his spare time.









		The Golden Horseshoe is a semi-annual meeting between collaborating researchers at Beaumont Hospital-Detroit, McMaster University, University of Rochester, University of Toronto, and Health Canada-Ottawa. The 2007 meeting, held on August 30th-31st at McMaster University focused on neutron radiobiology, low dose effects, and imaging.


				Click Here to download a PDF of the 2006-2007 Wet-Lab lecture schedule

		Dr. John Benitez Associate Professor of Emergency Medicine (University of Rochester) Preparations for Mass Medical Care Friday, June 1st • 4:00pm Cancer Center Conference Room (G-3111) Dr. Benitez became a member of the Toxicology Treatment Program at the University of Pittsburgh in 1991 starting and developing the medical toxicology fellowship, the occupational toxicology clinic, becoming the medical director of the Pittsburgh Poison Center in 1994. In 2000 he moved to Rochester, NY where he serves as the managing and associate medical director of the Ruth A. Lawrence Poison and Drug Information Center at the University of Rochester Medical Center. Dr. Benitez is board certified in Emergency Medicine (ABEM), Occupational Medicine (ABPM) and Medical Toxicology (ABPM). He was originally board certified by the American Board of Medical Toxicology. He is a member of the American Academy of Clinical Toxicology, American Association of Poison Control Centers, American College of Medical Toxicology (Fellow), American College of Preventive Medicine (Fellow), American College of Occupational and Environmental Medicine, and the American Academy of Emergency Medicine (Fellow). He has published numerous articles and book chapters on emergency medicine and medical toxicology. He has served as a consultant to the World Health Organization with its INTOX program. He teaches forensic toxicology, heat and altitude physiology, occupational medicine, medical toxicology (medical students and residents) and disaster preparedness as his primary focus. In addition Dr. Benitez is in charge of the decontamination team for the hospital.



		Dr. Andrew Karam Fellow—Center for Advanced Studies (Washington DC) NCRP, Dirty Bombs, and the ED Wednesday, May 14th • 4:30pm Cancer Center Conference Room (G-3111) Dr. Andrew Karam has extensive experience in radiological and nuclear safety, especially in the workplace, the environment, and in the military. He served as a reactor prototype training plant staff instructor on an attack nuclear submarine for the US Navy's nuclear power program for eight years. An internationally recognized authority, Dr. Karam served on the Health Physics Society’s Board of Directors, a National Academy of Sciences subcommittee on the effects of battlefield use of depleted uranium and on a committee for the National Council of Radiation Protection and Measurements. He works with local, state, national, and international organizations to help them prepare for the possibility of a terrorist attack – these include New York City, the city of Rochester, the State of New York, the Panama Canal Authority, and the Canadian Army.

		Dr. David J. Maguire Scientist-Nathan Node of Genomics Research Centre Professor-Biomolecular and Physical Sciences, Griffith University (Brisbane, Australia) Mitochondrial DNA: Responses to Age, Xenobiotics, and Radiation Wednesday, December 13th • 4:30pm Cancer Center Conference Room (G-3111) Dr. Maguire is a Scientist and leader of the Nathan Node of Genomics Research Centre and a Faculty member in the School of Biomolecular and Physical Science at Griffith University in Brisbane, Australia. His laboratory investigates the genomics of human cancer cells. A major focus of this research is also on the mitochondrial genome in healthy and diseased cells. This includes normal tissue culture cells as well as human tissue from a variety of sources. Recently, Dr. Maguire has turned increasing attention to the effects of xenobiotics and radiation upon mitochondrial DNA. Using real time PCR in conjunction with traditional methods of proteomics, he is investigating the metabolic consequences of such injurious insults at the cellular and tissue level. He also has an interest in collecting, extracting and testing natural products from the Australian environment for their ability to influence expression of the mitochondrial genome.

		The Golden Horseshoe is a semi-annual meeting between collaborating researchers at Beaumont Hospital-Detroit, McMaster University, University of Rochester, University of Toronto, and Health Canada-Ottawa. The 2006 meeting, held on October 19th-20th at the University of Rochester in NY, focused on Low-Dose Radiation.


		Dr. William Bernhard Professor-Biochemistry and Biophysics, University of Rochester Why radiation oncology exists: the mechanisms by which ionizing radiation damages DNA Wednesday, September 6th• 4:30pm (Cancer Center G-3111) The aim of our research program is to fully characterize the free radical processes by which ionizing radiation, through direct effects, alters the chemical structure of DNA. The ultimate goal is to develop a set of rules that will predict the chemical damage that results when DNA is exposed to ionizing radiation. Our approach is to use electron paramagnetic resonance (EPR) and electron nuclear double resonance (ENDOR) to study free radical processes initiated in DNA by ionizing radiation. Oligodeoxynucleotides of known sequence and predetermined crystal structure are used to investigate how the base sequence and local environment influence the distribution of electrons and holes trapped on DNA. The distribution, which effectively means the type and yield of trapped free radicals, is fundamental to understanding electron transfer, rearrangement, and radical combination reactions in DNA. The free radical reactions, ultimately terminate in stable diamagnetic damage. Using a variety of analytical tools, e.g., HPLC and NMR, stable end products are correlated with free radical precursors. Thus, we are able to discover the mechanisms by which initial ionization result in specific types of DNA damage, the damage that confronts the cells repair enzymes.

		Dr. Thomas Morgan Biological Basis for Radiation Control Regulations Tuesday, August 8th • 4:30pm Cancer Center Conference Room (G-3111) Dr. Morgan is the Radiation Safety Officer for the University of Rochester and Strong Memorial Hospital. He is certified by the American Board of Heath Physics in Comprehensive Health Physics and holds a New York State license to practice Medical Health Physics. He graduated with a Masters and a Ph.D. degree in Radiological Sciences from the University of California, Irvine. He is the author of 30 publications in radiation biology, human cancer genetics, clinical radiation oncology research and radiation protection. He has eleven years experience teaching radiation biology to residents and student radiation therapy technologists.

		Dr. Louis Peña Scientist-Brookhaven National Laboratory Radiation Protection by Synthetic Growth Factor Analogs Tuesday, July 18th • 4:30pm Cancer Center Conference Room (G-3111) Dr. Peña is a Scientist in the Medical Department at Brookhaven National Laboratory and a Faculty member in the Departments of Neuroscience and Biomedical Engineering at the State University of New York-Stony Brook. His laboratory investigates cellular and molecular mechanisms of radiation sensitivity, examining signaling pathways in order to develop drugs that protect normal cells or, conversely, sensitize tumor cells. A major focus of this research is also on non-neuronal cells of the CNS. This includes normal microvessel endothelial cells and glial cells such as oligodendrocytes. Recently, Dr. Peña and his team have developed a series of synthetic analogs of bFGF. Designated F2A3 and F2A4, these modular, synthetic molecules were shown to stimulate FGF receptors (FGFR1 and FGFR2) in a manner similar to the natural bFGF protein. They are employing them in models of radiation injury as well as applications for wound healing and tissue regeneration.

		Dr. John Bennet Professor Emeritus-James P. Wilmot Cancer Center, University of Rochester Long-Term Effects from Hiroshima and Nagasaki Thursday, June 1st• 8-9am Cancer Center Conference Room (G-3111) Dr. Bennett is Professor Emeritus of Medicine in the James P. Wilmot Cancer Center at the University of Rochester. He received his undergraduate degree from Harvard University and his medical degree from Boston University, both in Massachusetts. Postgraduate training included an internship at Massachusetts Memorial Hospital, a residency in medicine at Beth Israel Hospital, a fellowship in hematology at Bsoton City Hospital and Tufts University, and additional training at the NIH. He is a member of numerous professional societies, including the American Medical Association, American Association for the Advancement of Science, American Federation for Clinical Research, American Association for Cancer Research, American Society for Clinical Oncology, American Society of Hematology, and the International Society of Hematology. Dr. Bennett also serves as Chairman for the Myelodysplastic Syndromes Foundation. Dr. Bennett has contributed over 450 publications to the medical literature as well as several books, and he currently serves as Editor of Leukemia Research.

		Low-dose Radiobiology, Health Risks, and Assessment Symposium Douglas Boreham, PhD Associate Professor, Medical Physics and Applied Radiation Sciences McMaster University presentations include: Low Dose Radiobiology and Health Risks Douglas Boreham, PhD, McMaster University Environmental Radiation Risk Assessment in Non-Human Biota Cheryl Cassidy, McMaster University A Complex Dietary Supplement is a Potent Radioprotectant Jennifer Lemon, PhD, McMaster University ESR in Tooth Enamel for Emergency Dosimetry Jack Rink, PhD, McMaster University Apoptosis in Lymphocytes For Individual Radiation Sensitivity to Radiotherapy Douglas Boreham, PhD, McMaster University Cytogenetic Emergency Network for Emergency Biological Dosimetry Jo-Anna Dolling, PhD, FCCMG, McMaster University Genomic Instability and Spectral Karyotyping for Assessing Radiation Damage Dale Morris, McMaster University Friday, January 27th • 9:00-12:30 pm University of Rochester Medical Center • James P. Wilmot Cancer Center Conference Room (G-3111)

		Dr. Frederick Harper Scientist-Sandia National Laboratory Radiological Dispersal Device Aerosolization Experiments: History, Applications, and Results Wednesday, December 21st• 9-10am Cancer Center Conference Room (G-3111) Dr. Harper is Distinguished Member of Technical Staff, High Consequence Assessment and Technology Department at the Sandia National Laboratories, Albuquerque, New Mexico. He manages and performs research on the effects of chemical and biological releases from explosive and non-explosive dissemination mechanisms, and explosive aerosolization of nuclear materials from nuclear weapons and other nuclear sources. Dr. Harper has served as the U.S. delegate on numerous international and national working groups in the field of probabilistic risk assessment and consequence analysis, and developed computer codes for toxicological and radiological consequence assessment and accident progression. Dr. Harper earned a bachelor's degree from Yale University in Physics, a master's degree from the University of Virginia in Nuclear Engineering, and a doctorate, also in Nuclear Engineering, from the University of New Mexico.

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