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Richard Hill, Ph.D. (Leader, Project 5), senior scientist at the Ontario Cancer Institute/Princess Margaret Hospital (OCI/PMH) and a Professor in the departments of Medical Biophysics and Radiation Oncology at the University of Toronto. He is internationally recognized as a leader in the field of radiobiology. He has received numerous international honors for his work devoted to translational radiobiology with an emphasis on normal tissues. His work is respected for creativity, detail, and high relevance to public health. He is a sought after educator and his textbooks are used internationally to teach radiobiology.

Recent Publications

Hill RP, Kaspler P, Griffin AM, O'sullivan B, Catton C, Alasti H, Abbas A, Heydarian M, Ferguson P, Wunder JS, Bell RS. Studies of the in vivo radiosensitivity of human skin fibroblasts. Radiother Oncol. 2007 Jul;84(1):75-83. [abstract]
Zhang L, Subarsky P, Hill RP. Hypoxia-regulated p53 and its effect on radiosensitivity in cancer cells. Int J Radiat Biol. 2007 Jul;83(7):443-56. [abstract]
Chaudary N, Hill RP. Hypoxia and metastasis in breast cancer. Breast Dis. 2006-2007;26:55-64. Review. [abstract]
Chaudary N, Hill RP. Hypoxia and metastasis. Clin Cancer Res. 2007 Apr 1;13(7):1947-9. Review. [abstract]

Past Publications

Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006 Oct;82(10):699-757. Review. [abstract]
Fyles A, Milosevic M, Pintilie M, Syed A, Levin W, Manchul L, Hill RP. Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiother Oncol. 2006 Aug;80(2):132-7. [abstract]
Cruz-Munoz W, Sanchez OH, Di Grappa M, English JL, Hill RP, Khokha R. Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice. Oncogene. 2006 Oct 19;25(49):6489-96. [abstract]
Langan AR, Khan MA, Yeung IW, Van Dyk J, Hill RP. Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radiother Oncol. 2006 May;79(2):231-8. [abstract]
Calveley VL, Khan MA, Yeung IW, Vandyk J, Hill RP. Partial volume rat lung irradiation: Temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation. Int J Radiat Biol. 2006 Dec;81(12):887-99. [abstract]
Skliarenko JV, Lunt SJ, Gordon ML, Vitkin A, Milosevic M, Hill RP. Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors. Cancer Res. 2006 Feb 15;66(4):2074-80. [abstract]
Hill RP. Identifying cancer stem cells in solid tumors: case not proven. Cancer Res. 2006 Feb 15;66(4):1891-5. [abstract]
Katerinaki E, Haycock JW, Lalla R, Carlson KE, Yang Y, Hill RP, Lorigan PC, MacNeil S. Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells. Melanoma Res. 2006 Feb;16(1):11-22. [abstract]
Ellis AR, Fahie-Wilson M, Axcell M, Sands K, Hill RP. Macroprolactin(s): composition and reactivity in immunoassays and laboratory interpretation of results of an unusual patient serum. Ann Clin Biochem. 2006 Jan;43(Pt 1):57-62. [abstract]
Akudugu JM, Bell RS, Catton C, Davis AM, Griffin AM, O'Sullivan B, Waldron JN, Ferguson PC, Wunder JS, Hill RP. Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity. Radiother Oncol. 2006 Jan;78(1):17-26. [abstract]
Hill RP, MacNeil S, Haycock JW. Melanocyte stimulating hormone peptides inhibit TNF-alpha signaling in human dermal fibroblast cells. Peptides. 2006 Feb;27(2):421-30. [abstract]
Hill RP. Targeted treatment: insights from studies of osteopontin and hypoxia. Lancet Oncol. 2005 Oct;6(10):733-4. [abstract]
Hill RP. Radiation effects on the respiratory system. BJR Suppl. 2005;27:75-81. [abstract]
Hill RP, Wheeler P, MacNeil S, Haycock JW. Alpha-melanocyte stimulating hormone cytoprotective biology in human dermal fibroblast cells. Peptides. 2005 Jul;26(7):1150-8. [abstract]
Lolkema MP, Gervais ML, Snijckers CM, Hill RP, Giles RH, Voest EE, Ohh M. Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain. J Biol Chem. 2005 Jun 10;280(23):22205-11. [abstract]
Hedley DW, Nicklee T, Moreno-Merlo F, Pintilie M, Fyles A, Milosevic M, Hill RP. Relations between non-protein sulfydryl levels in the nucleus and cytoplasm, tumor oxygenation, and clinical outcome of patients with uterine cervical carcinoma. Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):137-44. [abstract]
Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, Dynan WS, Fike JR, Grdina DJ, Greenberger JS, Hauer-Jensen M, Hill RP, Kolesnick RN, Macvittie TJ, Marks C, McBride WH, Metting N, Pellmar T, Purucker M, Robbins ME, Schiestl RH, Seed TM, Tomaszewski JE, Travis EL, Wallner PE, Wolpert M, Zaharevitz D. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res. 2004 Dec;162(6):711-28. [abstract]
Sun T, Haycock JW, Szabo M, Hill RP, Macneil S. Measurement of NF-kappaB in normal and reconstructed human skin in vitro. J Mater Sci Mater Med. 2004 Jul;15(7):743-9. [abstract]

 
   
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