Recent Publications

Milano MT, Constine LS, Okunieff P. Normal tissue tolerance dose metrics for radiation therapy of major organs. Semin Radiat Oncol. 2007 Apr;17(2):131-40. [abstract]
Winey B, Misic V, Fenton B, Paoni S, Liao L, Okunieff P, Liu H, Parker K, Yu Y. In vivo Optical Spectroscopy of Acoustically Induced Blood Stasis. Conf Proc IEEE Eng Med Biol Soc. 2005;2:1449-52. [abstract]
Misic V, Winey B, Liu H, Liao L, Okunieff P, Parker K, Fenton B, Yu Y. Tumor Detection in vivo with Optical Spectroscopy. Conf Proc IEEE Eng Med Biol Soc. 2005;5:4708-11. [abstract]
Katz AW, Carey-Sampson M, Muhs AG, Milano MT, Schell MC, Okunieff P. Hypofractionated stereotactic body radiation therapy (SBRT) for limited hepatic metastases. Int J Radiat Oncol Biol Phys. 2007 Mar 1;67(3):793-8. Epub 2006 Dec 29. [abstract]
Wurm R, Okunieff P. Intracranial and extracranial stereotactic radiosurgery and radiotherapy. Int J Radiat Oncol Biol Phys. 2006 Nov 15;66(4 Suppl):S1-2. [abstract]
Okunieff P, Petersen AL, Philip A, Milano MT, Katz AW, Boros L, Schell MC. Stereotactic Body Radiation Therapy (SBRT) for lung metastases. Acta Oncol. 2006;45(7):808-17. [abstract]
Okunieff P. Design of multi-institutional and cooperative group studies of SBRT. Acta Oncol. 2006;45(7):775-8. [abstract]
Khor LY, Desilvio M, Li R, McDonnell TJ, Hammond ME, Sause WT, Pilepich MV, Okunieff P, Sandler HM, Pollack A. Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10. Int J Radiat Oncol Biol Phys. 2006 Sep 1;66(1):25-30. Epub 2006 Jul 11. [abstract]
Okunieff P, Xu J, Hu D, Liu W, Zhang L, Morrow G, Pentland A, Ryan JL, Ding I. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):890-8. [abstract]
Xiao Z, Su Y, Yang S, Yin L, Wang W, Yi Y, Fenton BM, Zhang L, Okunieff P. Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis. Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):882-9. [abstract]
Gao F, Okunieff P, Han Z, Ding I, Wang L, Liu W, Zhang J, Yang S, Chen J, Underhill CB, Kim S, Zhang L. Hypoxia-induced alterations in hyaluronan and hyaluronidase. Adv Exp Med Biol. 2005;566:249-56. [abstract]
Okunieff P, Fenton B, Chen Y. Past, present, and future of oxygen in cancer research. Adv Exp Med Biol. 2005;566:213-22. [abstract]
Liu W, Ding I, Chen K, Olschowka J, Xu J, Hu D, Morrow GR, Okunieff P. Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis. Radiat Res. 2006 Feb;165(2):181-91. [abstract]
Hickok JT, Morrow GR, Roscoe JA, Mustian K, Okunieff P. Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer. J Pain Symptom Manage. 2005 Nov;30(5):433-42. [abstract]
Hickok JT, Roscoe JA, Morrow GR, Mustian K, Okunieff P, Bole CW. Frequency, severity, clinical course, and correlates of fatigue in 372 patients during 5 weeks of radiotherapy for cancer. Cancer. 2005 Oct 15;104(8):1772-8. [abstract]
Khor LY, Desilvio M, Al-Saleem T, Hammond ME, Grignon DJ, Sause W, Pilepich M, Okunieff P, Sandler H, Pollack A; Radiation Therapy Oncology Group. MDM2 as a predictor of prostate carcinoma outcome: an analysis of Radiation Therapy Oncology Group Protocol 8610. Cancer. 2005 Sep 1;104(5):962-7. [abstract]

Past Publications

Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys. 2005;62(1):273-8. [abstract]
Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK. Regulation of prostaglandin E2 synthesis after brain irradiation. Int J Radiat Oncol Biol Phys. 2005;62(1):267-72. [abstract]
Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T, Rubin P. Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):260-6. [abstract]
Okunieff P, Schell MC, Ruo R, Hale ER, O'Dell WG, Pilcher W. Long-term management of patients with multiple brain metastases after shaped beam radiosurgery. Case report and review of the literature. J Neurosurg. 2004 Nov;101 Suppl 3:406-12. Review. [abstract]
Pardo FS, Hsu DW, Zeheb R, Efird JT, Okunieff PG, Malkin DM. Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage. Br J Cancer. 2004 Nov 1;91(9):1678-86. [abstract]
Souhami L, Seiferheld W, Brachman D, Podgorsak EB, Werner-Wasik M, Lustig R, Schultz CJ, Sause W, Okunieff P, Buckner J, Zamorano L, Mehta MP, Curran WJ Jr. Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of RTOG 93-05 protocol. Int J Radiat Oncol Biol Phys. 2004;60(3):853-60. [abstract]
Ding I, Okunieff P, Salnikow K, Liu W, Fenton B. A new intrinsic hypoxia marker in esophageal cancer. Adv Exp Med Biol. 2003;540:227-33.
Okunieff P, Augustine E, Hicks JE, Cornelison TL, Altemus RM, Naydich BG, Ding I, Huser AK, Abraham EH, Smith JJ, Coleman N, Gerber LH. Pentoxifylline in the treatment of radiation-induced fibrosis. J Clin Oncol. 2004 Jun 1;22(11):2207-13. [abstract]
Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004 May;161(5):560-7. [abstract]
Chen Y, Okunieff P. Radiation and third-generation chemotherapy. Hematol Oncol Clin North Am. 2004 Feb;18(1):55-80. Review [abstract]
Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin T, Williams JP, Messing E, Okunieff P. Is there a favorable subset of patients with prostate cancer who develop oligometastases? Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):3-10. [abstract]
Ding I, Liu W, Sun J, Paoni SF, Hernady E, Fenton BM, Okunieff P. FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice. Adv Exp Med Biol. 2003;530:603-9. [abstract]
Okunieff P, Fenton BM, Zhang L, Kern FG, Wu T, Greg JR, Ding I. Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density. Adv Exp Med Biol. 2003;530:593-601.
Zhong J, Kwok WC, Okunieff P. fMRI for monitoring dynamic changes in tissue oxygenation/blood flow: potential applications for tumor response to carbogen treatment. Adv Exp Med Biol. 2003;530:449-59.
Okunieff P, Meyn RE, Teicher BA, Thomas CR Jr, Gaspar LE, Raben D, Giri S, Lavey RS, Turrisi AT 3rd, Swanson GP, Smalley SR; Radiation Oncology Committee of the Southwest Oncology Group. Report from the Radiation Oncology Committee of the Southwest Oncology Group (SWOG): Research Objectives Workshop 2003. Am J Clin Oncol. 2003 Oct;26(5):522-9. [abstract]
Chen Y, Okunieff P, Ahrendt SA. Translational research in lung cancer. Semin Surg Oncol. 2003;21(3):205-19. Review. [abstract]
Chakravarti A, Heydon K, Wu CL, Hammond E, Pollack A, Roach M, Wolkov H, Okunieff P, Cox J, Fontanesi J, Abrams R, Pilepich M, Shipley W; Radiation Therapy Oncology Group. Loss of p16 expression is of prognostic significance in locally advanced prostate cancer: an analysis from the Radiation Therapy Oncology Group protocol 86-10. J Clin Oncol. 2003;21(17):3328-34.[abstract]
Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff P. The biological basis of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003l;13:182-8.[abstract]
Biswas T, Sandhu AP, Singh DP, Schell MC, Maciunas RJ, Bakos RS, Muhs AG, Okunieff P. Low-dose radiosurgery for benign intracranial lesions. Am J Clin Oncol. 2003 Aug;26(4):325-31.[abstract]
Liang L, Hu D, Liu W, Williams JP, Okunieff P, Ding I. Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am J Clin Oncol. 2003 Aug;26(4):S114-21.[abstract]
Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. Am J Clin Oncol. 2003 Aug;26(4):S103-9. [abstract]
Chen Y, Pandya K, Keng PC, Johnstone D, Li J, Lee YJ, Smudzin T, Okunieff P. Phase I/II clinical study of pulsed paclitaxel radiosensitization for thoracic malignancy: a therapeutic approach on the basis of preclinical research of human cancer cell lines. Clin Cancer Res 2003;9(3):969-75.[abstract]
Liu H, Yu Y, Schell MC, O'Dell WG, Ruo R, Okunieff P. Optimal marker placement in photogrammetry patient positioning system. Med Phys. 2003 Feb;30(2):103-10. [abstract]
Okunieff P, Ding I, Vaupel P, Höckel M. Evidence for and against hypoxia as the primary cause of tumor aggressiveness. Adv Exp Med Biol. 2003;510:69-75.
Ding I, Liu W, Sun J, Fenton B, Okunieff P. Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas. Comp Biochem Physiol A Mol Integr Physiol. 2002 May;132(1):17-25. [abstract]
Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin T, Finkelstein JN, Rubin P, Okunieff P. Radiation pneumonitis and early circulatory cytokine markers. Semin Radiat Oncol. 2002 Jan;12(1 Suppl 1):26-33. [abstract]
Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res. 2002 Mar;157(3):256-65. [abstract]
Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiat Res. 2002 Jan;157(1):62-8. [abstract]
Chen Y, Taghian AG, Rosenberg AE, O'Connell J, Okunieff P, Suit HD. Predictive value of histologic tumor necrosis after radiation. Int J Cancer. 2001 Dec 20;96(6):334-40. [abstract]
Hammond ME, Ang K, Byhardt R, Campbell B, Chapman JD, Eisenberg B, Greven K, Harris J, Hoffman J, Lange C, McCormick B, Mehta M, Sandler H, Trotti A, Willet C, Wolfson A, Furness A, Jensen T, Grignon D, Okunieff P; Radiation Therapy Oncology Group. Radiation Therapy Oncology Group. Research Plan 2002-2006. Tumor Utilization Committee. Int J Radiat Oncol Biol Phys. 2001;51(3 Suppl 2):103-9.
Okunieff P, Hammond E, Grignon D, Langer C, Pajak TF, Ang K, Bruner DW, Travis E, Greven K, Guha A, Moulder J, Pollack A, Scarantino C, Sneige N, Watson J, Amin M, Bondy M, Chakravarti A, Chapman JD, Dicker A, Harris J, Koch W, Komaki R, Lange C, McBride W, Mitchell J, Milas L, Movsas B, Pandya K, Pienta K, Regine W, Ritter M, Rubin P, Safran H, Sauter E, Schell M, Stevens C, Trotti A, Vikram B; Radiation Therapy Oncology Group. Radiation Therapy Oncology Group. Research Plan 2002-2006. Translational Research Program. Int J Radiat Oncol Biol Phys. 2001;51(3 Suppl 2):75-87.
Watkins Bruner D, Berk L, Bondy M, Kachnic LA, Konski A, Layne E, Lee WR, Choucair A, Movsas B, Okunieff P, Roach M 3rd, Scott C, Vijayakumar S, Wenzel L; Radiation Therapy Oncology Group. Radiation Therapy Oncology Group. Research Plan 2002-2006. Outcomes Committee. Int J Radiat Oncol Biol Phys. 2001;51(3 Suppl 2):66-74.
Okunieff P, Li M, Liu W, Sun J, Fenton B, Zhang L, Ding I. Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma. Am J Clin Oncol. 2001;24(5):491-5.[abstract]
Fenton BM, Beauchamp BK, Paoni SF, Okunieff P, Ding I. Characterization of the effects of antiangiogenic agents on tumor pathophysiology. Am J Clin Oncol. 2001;24(5):453-7.[abstract]