Dr. Jacob Finkelstein (Co-PI)

Recent Publications

Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black. J Occup Environ Med. 2006 Dec;48(12):1265-78. [abstract]
Oberdorster G, Finkelstein JN. In vitro dosing of cells with poorly soluble particles. Toxicol Sci. 2006 Dec;94(2):439. [abstract]
Johnston CJ, Holm BA, Gelein R, Finkelstein JN. Postnatal lung development: immediate-early gene responses post ozone and LPS exposure. Inhal Toxicol. 2006 Oct;18(11):875-83. [abstract]
Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1101-11. [abstract]
Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol. 2006 Jun;168(6):1838-47. [abstract]

Past Publications

Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys. 2005;62(1):273-8. [abstract]
Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdorster G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci. 2005;88(2):614-29. [abstract]
Johnston CJ, Holm BA, Finkelstein JN. Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses. Exp Lung Res. 2005;31(4):431-47. [abstract]
Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. Inhal Toxicol. 2005;17(9):415-25. [abstract]
Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Exp Lung Res. 2005;31(6):581-97. [abstract]
Chess PR, O'Reilly MA, Sachs F, Finkelstein JN. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol. 2005;99(3):1226-32. [abstract]
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 2004;30(5):369-82. [abstract]
Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004;161(5):560-7. [abstract]
Finkelstein JN, Johnston CJ. Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress. Pediatrics. 2004;113(4 Suppl):1092-6. [abstract]
D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am J Physiol Lung Cell Mol Physiol. 2004;286(1):L30-6. [abstract]
Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdorster G. Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol. 2000;12 Suppl 4:227-46. [abstract]
Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res. 2002;157(3):256-65. [abstract]

	people: over fifty scientists and one goal...

		In addition to his nationally and internationally recognized research in the area of particle inhalation, Dr. Finkelstein has performed studies in acute and chronic inflammatory lung injury following a number of different insults including radiation, hypoxia and silica, as well as studies of gene expression in isolated lung cells. Dr. Finkelstein's laboratory has published extensively on aspects of particulate- and radiation-induced lung injury. Dr. Finkelstein also has been involved with the Environmental Health and Safety Center's Pilot Project Program as its Director for the past 6 years. He implemented the two tier review mechanism currently used in that program. He is the recipient of the Medical School’s highest award for education awarded by the medical students.





		Recent Publications Carter JM, Corson N, Driscoll KE, Elder A, Finkelstein JN, Harkema JN, Gelein R, Wade-Mercer P, Nguyen K, Oberdorster G. A comparative dose-related response of several key pro- and antiinflammatory mediators in the lungs of rats, mice, and hamsters after subchronic inhalation of carbon black. J Occup Environ Med. 2006 Dec;48(12):1265-78. [abstract] Oberdorster G, Finkelstein JN. In vitro dosing of cells with poorly soluble particles. Toxicol Sci. 2006 Dec;94(2):439. [abstract] Johnston CJ, Holm BA, Gelein R, Finkelstein JN. Postnatal lung development: immediate-early gene responses post ozone and LPS exposure. Inhal Toxicol. 2006 Oct;18(11):875-83. [abstract] Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA. Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development. Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1101-11. [abstract] Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA. p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth. Am J Pathol. 2006 Jun;168(6):1838-47. [abstract] Past Publications Okunieff P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams JP, Finkelstein J. Mechanism and modification of gastrointestinal soft tissue response to radiation: role of growth factors. Int J Radiat Oncol Biol Phys. 2005;62(1):273-8. [abstract] Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdorster G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci. 2005;88(2):614-29. [abstract] Johnston CJ, Holm BA, Finkelstein JN. Sequential exposures to ozone and lipopolysaccharide in postnatal lung enhance or inhibit cytokine responses. Exp Lung Res. 2005;31(4):431-47. [abstract] Singal M, Finkelstein JN. Use of indicator cell lines for determining inflammatory gene changes and screening the inflammatory potential of particulate and non-particulate stimuli. Inhal Toxicol. 2005;17(9):415-25. [abstract] Singal M, Finkelstein JN. Amorphous silica particles promote inflammatory gene expression through the redox sensitive transcription factor, AP-1, in alveolar epithelial cells. Exp Lung Res. 2005;31(6):581-97. [abstract] Chess PR, O'Reilly MA, Sachs F, Finkelstein JN. Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells. J Appl Physiol. 2005;99(3):1226-32. [abstract] Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein JN. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res. 2004;30(5):369-82. [abstract] Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004;161(5):560-7. [abstract] Finkelstein JN, Johnston CJ. Enhanced sensitivity of the postnatal lung to environmental insults and oxidant stress. Pediatrics. 2004;113(4 Suppl):1092-6. [abstract] D'Angio CT, LoMonaco MB, Johnston CJ, Reed CK, Finkelstein JN. Differential roles for NF-kappa B in endotoxin and oxygen induction of interleukin-8 in the macrophage. Am J Physiol Lung Cell Mol Physiol. 2004;286(1):L30-6. [abstract] Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdorster G. Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol. 2000;12 Suppl 4:227-46. [abstract] Johnston CJ, Williams JP, Okunieff P, Finkelstein JN. Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families. Radiat Res. 2002;157(3):256-65. [abstract]







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