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Jacqueline
Williams, Ph.D. (Leader, Training and Education Core), Associate Professor,
Department of Radiation Oncology. Dr. Williams trained in Radiation Biology
at the University of London (St. Bartholomew's Medical College), a department
whose alumni included Drs. John Coggle, Barrie Lambert, Patricia Lindop,
and the Nobel Prize winner, Dr. Joseph Rotblat. She is an active educator
in the Radiation Biology teaching course for
Radiation Oncology residents in the University of Rochester Medical School.
She is also a frequent lecturer to residents in other upstate institutions,
including Roswell Park Cancer Center, Buffalo, NY. Dr. Williams' interest
in education also has led to her involvement as an Associate Editor for
RABEX (Radiobiology Practice Examinations), recently renamed the ASTRO
Radiation/Cancer Biology Practice Examination and Study Guide. Dr. Williams
has worked in radiobiologically-oriented research since the early 1980's,
studies that began at Bart's investigating the development of skin carcinogenesis
following localized beta-particle exposure. In her time at the University
of Rochester, her work has focused on other aspects of radiation-induced
late effects, emphasizing vasculature and brain, and, in
particular, lung effects. Finally, Dr. Williams is the Program Director
of Radiation Medicine in the University of Rochester's Center for Disaster
Medicine and Emergency Preparedness.
Recent Publications
Okunieff
P, Cornelison T, Mester M, Liu W, Ding I, Chen Y, Zhang H, Williams
JP, Finkelstein J. Mechanism and modification of gastrointestinal
soft tissue response to radiation: role of growth factors. Int J Radiat
Oncol Biol Phys. 2005;62(1):273-8. [abstract]
Johnston CJ, Williams JP, Elder A, Hernady E, Finkelstein
JN. Inflammatory cell recruitment following thoracic irradiation. Exp
Lung Res. 2004;30(5):369-82. [abstract]
Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton
B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin
on the development of late pulmonary effects after whole-lung irradiation
in a murine model. Radiat Res. 2004;161(5):560-7. [abstract]
Moore AH,
Olschowka JA, Williams JP, Okunieff
P, O'Banion MK. Regulation of prostaglandin E2 synthesis after brain
irradiation. Int J Radiat Oncol Biol Phys. 2005;62(1):267-72. [abstract]
Chen Y, Hyrien O, Williams J, Okunieff P, Smudzin T,
Rubin P. Interleukin (IL)-1A and IL-6: applications to the predictive
diagnostic testing of radiation pneumonitis. Int J Radiat Oncol Biol
Phys. 2005 May 1;62(1):260-6. [abstract]
Singh D, Yi WS, Brasacchio RA, Muhs AG, Smudzin T, Williams
JP, Messing E, Okunieff P. Is there a favorable subset of patients
with prostate cancer who develop oligometastases? Int J Radiat Oncol
Biol Phys. 2004 Jan 1;58(1):3-10. [abstract]
Williams J, Chen Y, Rubin P, Finkelstein J, Okunieff
P. The biological basis of a comprehensive grading system for the adverse
effects of cancer treatment. Semin Radiat Oncol 2003l;13:182-8.[abstract]
Liang L, Hu D, Liu W, Williams JP, Okunieff P, Ding
I. Celecoxib reduces skin damage after radiation: selective reduction
of chemokine and receptor mRNA expression in irradiated skin but not
in irradiated mammary tumor. Am J Clin Oncol. 2003 Aug;26(4):S114-21.[abstract]
Chen Y, Williams J, Ding I, Hernady E, Liu W, Smudzin
T, Finkelstein JN, Rubin P, Okunieff P. Radiation pneumonitis and early
circulatory cytokine markers. Semin Radiat Oncol. 2002 Jan;12(1 Suppl
1):26-33. [abstract]
Johnston CJ, Williams JP, Okunieff P, Finkelstein JN.
Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine
receptor families. Radiat Res. 2002 Mar;157(3):256-65. [abstract]
