Dr. Harold Swartz (Project Leader)

Recent Publications

Abramovic Z, Sentjurc M, Kristl J, Khan N, Hou H, Swartz HM. Influence of different anesthetics on skin oxygenation studied by electron paramagnetic resonance in vivo. Skin Pharmacol Physiol. 2007;20(2):77-84. [abstract]
Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006 Oct;82(10):699-757. [abstract]
Swartz HM, Iwasaki A, Walczak T, Demidenko E, Salikhov I, Khan N, Lesniewski P, Thomas J, Romanyukha A, Schauer D, Starewicz P. In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation. Radiat Prot Dosimetry. 2006;120(1-4):163-70. Epub 2006 Apr 27. [abstract]
Sakata YS, Grinberg OY, Grinberg S, Springett R, Swartz HM. Simultaneous NIR-EPR spectroscopy of rat brain oxygenation. Adv Exp Med Biol. 2005;566:357-62. [abstract]
Swartz HM, Dunn J. The difficulties in comparing in vivo oxygen measurements: turning the problems into virtues. Adv Exp Med Biol. 2005;566:295-301. [abstract]
Hou H, Grinberg OY, Grinberg SA, Khan N, Dunn JF, Swartz HM. Cerebral PtO2, acute hypoxia, and volatile anesthetics in the rat brain. Adv Exp Med Biol. 2005;566:179-85. [abstract]
Grinberg O, Novozhilov B, Grinberg S, Friedman B, Swartz HM. Axial oxygen diffusion in the Krogh model: modifications to account for myocardial oxygen tension in isolated perfused rat hearts measured by EPR oximetry. Adv Exp Med Biol. 2005;566:127-34. [abstract]
Khan N, Hou H, Hein P, Comi RJ, Buckey JC, Grinberg O, Salikhov I, Lu SY, Wallach H, Swartz HM. Black magic and EPR oximetry: from lab to initial clinical trials. Adv Exp Med Biol. 2005;566:119-25. [abstract]
Grinberg OY, Hou H, Roche MA, Merlis J, Grinberg SA, Khan N, Swartz HM, Dunn JF. Modeling of the response of ptO2 in rat brain to changes in physiological parameters. Adv Exp Med Biol. 2005;566:111-8. [abstract]
Helisch A, Wagner S, Khan N, Drinane M, Wolfram S, Heil M, Ziegelhoeffer T, Brandt U, Pearlman JD, Swartz HM, Schaper W. Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):520-6. [abstract]

Past Publications

Dinguizli M, Jeumont S, Beghein N, He J, Walczak T, Lesniewski PN, Hou H, Grinberg OY, Sucheta A, Swartz HM, Gallez B. Development and evaluation of biocompatible films of polytetrafluoroethylene polymers holding lithium phthalocyanine crystals for their use in EPR oximetry. Biosens Bioelectron. 2006;21(7):1015-22. [abstract]
Salikhov I, Walczak T, Lesniewski P, Khan N, Iwasaki A, Comi R, Buckey J, Swartz HM. EPR spectrometer for clinical applications. Magn Reson Med. 2005;54(5):1317-20. [abstract]
Hou H, Khan N, O'Hara JA, Grinberg OY, Dunn JF, Abajian MA, Wilmot CM, Demidenko E, Lu S, Steffen RP, Swartz HM. Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005;61(5):1503-9. [abstract]
O'Hara JA, Hou H, Demidenko E, Springett RJ, Khan N, Swartz HM. Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia. Physiol Meas. 2005;26(3):203-13. [abstract]
Hou H, Grinberg OY, Grinberg SA, Demidenko E, Swartz HM. Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurements. Physiol Meas. 2005;26(1):131-41. [abstract]
O'Hara JA, Khan N, Hou H, Wilmo CM, Demidenko E, Dunn JF, Swartz HM. Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2. Physiol Meas. 2004;25(6):1413-23. [abstract]
Khan N, Grinberg O, Wilmot C, Kiefer H, Swartz HM. "Distant spin trapping": a method for expanding the availability of spin trapping measurements. J Biochem Biophys Methods. 2005;62(2):125-30. [abstract]
Swartz HM, Iwasaki A, Walczak T, Demidenko E, Salikov I, Lesniewski P, Starewicz P, Schauer D, Romanyukha A. Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ. Appl Radiat Isot. 2005;62(2):293-9. [abstract]
Romanyukha AA, Ivanov D, Schauer DA, Thomas JA, Swartz HM. Spectrum file size optimization for EPR tooth dosimetry. Appl Radiat Isot. 2005;62(2):197-200. [abstract]
Iwasaki A, Grinberg O, Walczak T, Swartz HM. In vivo measurements of EPR signals in whole human teeth. Appl Radiat Isot. 2005;62(2):187-90. [abstract]
Iwasaki A, Walczak T, Grinberg O, Swartz HM. Differentiation of the observed low frequency (1200MHz) EPR signals in whole human teeth. Appl Radiat Isot. 2005 Feb;62(2):133-9. [abstract]
Swartz HM, Khan N, Buckey J, Comi R, Gould L, Grinberg O, Hartford A, Hopf H, Hou H, Hug E, Iwasaki A, Lesniewski P, Salikhov I, Walczak T. Clinical applications of EPR: overview and perspectives. NMR Biomed. 2004 Aug;17(5):335-51. Review. [abstract]
Gallez B, Swartz HM. In vivo EPR: when, how and why? NMR Biomed. 2004 Aug;17(5):223-5. [abstract]
Grinberg OY, Hou H, Grinberg SA, Moodie KL, Demidenko E, Friedman BJ, Post MJ, Swartz HM. pO2 and regional blood flow in a rabbit model of limb ischemia. Physiol Meas. 2004 Jun;25(3):659-70. [abstract]
Hou H, Khan N, O'Hara JA, Grinberg OY, Dunn JF, Abajian MA, Wilmot CM, Makki M, Demidenko E, Lu S, Steffen RP, Swartz HM. Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study. Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):834-43. [abstract]
Swartz HM. Using EPR to measure a critical but often unmeasured component of oxidative damage: oxygen. Antioxid Redox Signal. 2004 Jun;6(3):677-86. Review. [abstract]
James PE, Madhani M, Ross C, Klei L, Barchowsky A, Swartz HM. Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide. Adv Exp Med Biol. 2003;530:645-52. [abstract]
Swartz HM, Taie S, Miyake M, Grinberg OY, Hou H, el-Kadi H, Dunn JF. The effects of anesthesia on cerebral tissue oxygen tension: use of EPR oximetry to make repeated measurements. Adv Exp Med Biol. 2003;530:569-75. [abstract]
Miyake M, Grinberg OY, Hou H, Steffen RP, Elkadi H, Swartz HM. The effect of RSR13, a synthetic allosteric modifier of hemoglobin, on brain tissue pO2 (measured by EPR oximetry) following severe hemorrhagic shock in rats. Adv Exp Med Biol. 2003;530:319-29. [abstract]

	people: over fifty scientists and one goal...

		Harold Swartz, M.D., Ph.D. (Leader, Project 3), Professor and Director of Radiological Research at the Dartmouth Medical School. He is also Director of the MD/PhD Program at Dartmouth Medical School and Director of Educational Programs. He has been involved in the field of biodosimetry using ESR for over 30 years. He was Director, Biophysics Department, Walter Reed Army Institute of Research (1966-1969) and Director, Department of Biological Chemistry, Walter Reed Army Institute of Research (1970). Dr. Swartz has degrees in radiobiology (University of North Carolina), biochemistry (Georgetown), and medicine (University of Illinois). He is a recipient of the Silver Medal from the International EPR Society, and a recipient of the Silver Medal from the Society for Magnetic Resonance in Medicine.






		Recent Publications Abramovic Z, Sentjurc M, Kristl J, Khan N, Hou H, Swartz HM. Influence of different anesthetics on skin oxygenation studied by electron paramagnetic resonance in vivo. Skin Pharmacol Physiol. 2007;20(2):77-84. [abstract] Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006 Oct;82(10):699-757. [abstract] Swartz HM, Iwasaki A, Walczak T, Demidenko E, Salikhov I, Khan N, Lesniewski P, Thomas J, Romanyukha A, Schauer D, Starewicz P. In vivo EPR dosimetry to quantify exposures to clinically significant doses of ionising radiation. Radiat Prot Dosimetry. 2006;120(1-4):163-70. Epub 2006 Apr 27. [abstract] Sakata YS, Grinberg OY, Grinberg S, Springett R, Swartz HM. Simultaneous NIR-EPR spectroscopy of rat brain oxygenation. Adv Exp Med Biol. 2005;566:357-62. [abstract] Swartz HM, Dunn J. The difficulties in comparing in vivo oxygen measurements: turning the problems into virtues. Adv Exp Med Biol. 2005;566:295-301. [abstract] Hou H, Grinberg OY, Grinberg SA, Khan N, Dunn JF, Swartz HM. Cerebral PtO2, acute hypoxia, and volatile anesthetics in the rat brain. Adv Exp Med Biol. 2005;566:179-85. [abstract] Grinberg O, Novozhilov B, Grinberg S, Friedman B, Swartz HM. Axial oxygen diffusion in the Krogh model: modifications to account for myocardial oxygen tension in isolated perfused rat hearts measured by EPR oximetry. Adv Exp Med Biol. 2005;566:127-34. [abstract] Khan N, Hou H, Hein P, Comi RJ, Buckey JC, Grinberg O, Salikhov I, Lu SY, Wallach H, Swartz HM. Black magic and EPR oximetry: from lab to initial clinical trials. Adv Exp Med Biol. 2005;566:119-25. [abstract] Grinberg OY, Hou H, Roche MA, Merlis J, Grinberg SA, Khan N, Swartz HM, Dunn JF. Modeling of the response of ptO2 in rat brain to changes in physiological parameters. Adv Exp Med Biol. 2005;566:111-8. [abstract] Helisch A, Wagner S, Khan N, Drinane M, Wolfram S, Heil M, Ziegelhoeffer T, Brandt U, Pearlman JD, Swartz HM, Schaper W. Impact of mouse strain differences in innate hindlimb collateral vasculature. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):520-6. [abstract] Past Publications Dinguizli M, Jeumont S, Beghein N, He J, Walczak T, Lesniewski PN, Hou H, Grinberg OY, Sucheta A, Swartz HM, Gallez B. Development and evaluation of biocompatible films of polytetrafluoroethylene polymers holding lithium phthalocyanine crystals for their use in EPR oximetry. Biosens Bioelectron. 2006;21(7):1015-22. [abstract] Salikhov I, Walczak T, Lesniewski P, Khan N, Iwasaki A, Comi R, Buckey J, Swartz HM. EPR spectrometer for clinical applications. Magn Reson Med. 2005;54(5):1317-20. [abstract] Hou H, Khan N, O'Hara JA, Grinberg OY, Dunn JF, Abajian MA, Wilmot CM, Demidenko E, Lu S, Steffen RP, Swartz HM. Increased oxygenation of intracranial tumors by efaproxyn (efaproxiral), an allosteric hemoglobin modifier: In vivo EPR oximetry study. Int J Radiat Oncol Biol Phys. 2005;61(5):1503-9. [abstract] O'Hara JA, Hou H, Demidenko E, Springett RJ, Khan N, Swartz HM. Simultaneous measurement of rat brain cortex PtO2 using EPR oximetry and a fluorescence fiber-optic sensor during normoxia and hyperoxia. Physiol Meas. 2005;26(3):203-13. [abstract] Hou H, Grinberg OY, Grinberg SA, Demidenko E, Swartz HM. Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurements. Physiol Meas. 2005;26(1):131-41. [abstract] O'Hara JA, Khan N, Hou H, Wilmo CM, Demidenko E, Dunn JF, Swartz HM. Comparison of EPR oximetry and Eppendorf polarographic electrode assessments of rat brain PtO2. Physiol Meas. 2004;25(6):1413-23. [abstract] Khan N, Grinberg O, Wilmot C, Kiefer H, Swartz HM. "Distant spin trapping": a method for expanding the availability of spin trapping measurements. J Biochem Biophys Methods. 2005;62(2):125-30. [abstract] Swartz HM, Iwasaki A, Walczak T, Demidenko E, Salikov I, Lesniewski P, Starewicz P, Schauer D, Romanyukha A. Measurements of clinically significant doses of ionizing radiation using non-invasive in vivo EPR spectroscopy of teeth in situ. Appl Radiat Isot. 2005;62(2):293-9. [abstract] Romanyukha AA, Ivanov D, Schauer DA, Thomas JA, Swartz HM. Spectrum file size optimization for EPR tooth dosimetry. Appl Radiat Isot. 2005;62(2):197-200. [abstract] Iwasaki A, Grinberg O, Walczak T, Swartz HM. In vivo measurements of EPR signals in whole human teeth. Appl Radiat Isot. 2005;62(2):187-90. [abstract] Iwasaki A, Walczak T, Grinberg O, Swartz HM. Differentiation of the observed low frequency (1200MHz) EPR signals in whole human teeth. Appl Radiat Isot. 2005 Feb;62(2):133-9. [abstract] Swartz HM, Khan N, Buckey J, Comi R, Gould L, Grinberg O, Hartford A, Hopf H, Hou H, Hug E, Iwasaki A, Lesniewski P, Salikhov I, Walczak T. Clinical applications of EPR: overview and perspectives. NMR Biomed. 2004 Aug;17(5):335-51. Review. [abstract] Gallez B, Swartz HM. In vivo EPR: when, how and why? NMR Biomed. 2004 Aug;17(5):223-5. [abstract] Grinberg OY, Hou H, Grinberg SA, Moodie KL, Demidenko E, Friedman BJ, Post MJ, Swartz HM. pO2 and regional blood flow in a rabbit model of limb ischemia. Physiol Meas. 2004 Jun;25(3):659-70. [abstract] Hou H, Khan N, O'Hara JA, Grinberg OY, Dunn JF, Abajian MA, Wilmot CM, Makki M, Demidenko E, Lu S, Steffen RP, Swartz HM. Effect of RSR13, an allosteric hemoglobin modifier, on oxygenation in murine tumors: an in vivo electron paramagnetic resonance oximetry and bold MRI study. Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):834-43. [abstract] Swartz HM. Using EPR to measure a critical but often unmeasured component of oxidative damage: oxygen. Antioxid Redox Signal. 2004 Jun;6(3):677-86. Review. [abstract] James PE, Madhani M, Ross C, Klei L, Barchowsky A, Swartz HM. Tissue hypoxia during bacterial sepsis is attenuated by PR-39, an antibacterial peptide. Adv Exp Med Biol. 2003;530:645-52. [abstract] Swartz HM, Taie S, Miyake M, Grinberg OY, Hou H, el-Kadi H, Dunn JF. The effects of anesthesia on cerebral tissue oxygen tension: use of EPR oximetry to make repeated measurements. Adv Exp Med Biol. 2003;530:569-75. [abstract] Miyake M, Grinberg OY, Hou H, Steffen RP, Elkadi H, Swartz HM. The effect of RSR13, a synthetic allosteric modifier of hemoglobin, on brain tissue pO2 (measured by EPR oximetry) following severe hemorrhagic shock in rats. Adv Exp Med Biol. 2003;530:319-29. [abstract]







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