The Center for Biophysical Assessment and Risk Management Following Irradiation exists to bring together the knowledge, technologies, and effort of a multidisciplinary, international team of scientific personnel in order to develop medical countermeasures to radiological terrorism. The Center housed at the University of Rochester is one of 8 NIH/NIAID funded centers throughout the United States.
  
 

Our CMCR is focused on the development of medical countermeasures to assess, diagnose, and treat those exposed to radiation by developing (1) methods for rapid, high throughput assessment or measurement of radiation exposure through both bioassays and instruments, and (2) agents for mitigation and treatment of radiation effects with an emphasis on early and late side effects in non-hematopoietic tissues. Given both the urgent need to develop and validate medical countermeasures to seemingly imminent radiological and nuclear threats, and the dearth of available assessment tools or therapies, our short-term Center goal has been to develop and validate a number of therapeutic agents and radiation exposure assessment devices as quickly as possible, at least to the point of usefulness and availability for an emergency situation. Such a requirement is driven by the need for emergency/disaster response teams to be able to rapidly identify those who are contaminated with radioactive material and reassure those who are not, assess the extent/dose of radiation exposure, and administer appropriate treatment. Our expectation is to accelerate the development of our dosimeters and discriminators (methods of screening for radiation exposure which do not measure dose) as well as 2 or 3 of our most promising therapeutic agents that can be offered to victims (and rescue workers) to mitigate early and/or late non-hematopoietic effects.

  
 

PROJECT 1
Project 1 has demonstrated progress with a number of agents that may prove useful in radiation mitigation and/or treatment. These include EsA in skin and lung. The University of Rochester has licensed h-EsA, a derivative of EsA synthesized, tested, and patented by scientists in Project 1. In addition, testing of customized Curcumin analogs and customized FGF analogs has suggested that these agents may provide both protection and mitigation of the acute gastrointestinal syndrome in addition to both early and late cutaneous radiation toxicity. FGF and its analogs are expected to be beneficial against gastrointestinal syndrome. They also have important activity for the bone marrow syndrome and may have benefit for radiation dermatitis and pneumonitis. FGF-P is an outgrowth of our research on FGF based radioprotector drugs and was designed and synthesized by scientists in Project 1. A patent has been applied for this agent that is proven to bind to the FGFR1 receptor with a binding coefficient similar to that of native basic FGF (FGF2).
PROJECT 2
Our top accomplishment in 2008 involves the initial studies using radioactive cesium particles. These studies were logistically difficult to begin, but in collaboration with our Radiation Safety personnel, the distribution and elimination of injected particles has been assessed, and tissues, including blood, are being analyzed. Data suggests that this model may have additional utility for evaluating bone marrow effects. Most importantly, Project 2 has established a low dose lung late effect model and are currently evaulating the effects of mitigators with varying mechanisms on the development of the pathology. It appears that effects of radiation alone at the doses specified by the original proposal are limited to patchy septal thickening and cellular infiltrates. A more significant outcome appears to be detected if the lung is subjected to a secondary stress, namely an innate immune challenge. Altered lung responses persist for months after treatment. This may be of great significance as it relates to the effect of widespread human exposure and the ability to appropriately triage.
We have also established a rodent model of internal contaminationand are collaborating with CMCR researchers to evaluate pulmonary, GI, and hematological effects.
PROJECT 3
Major accomplishments in tooth dosimetry include deployment of a transportable system, the development of an accurate mouth model to facilitate further instrumental and analytic developments, and refinement of data averaging techniques. Decomposition of the mechanically induced signal in fingernails indicates a consistency across subjects that could be used to distinguish between these signals and the desired radiation-induced signal. This new insight may provide a means to analyze spectra from untreated fingernails clippings in the field and facilitate rapid screening for >2 Gy discrimination and the potential for accurate dose estimation.
PROJECT 4
The 3-D human bone marrow culture is essential to the support of MN-RET as radiation dose estimate in humans. It holds great promise as an ex vivo culture systems to investigate the potential effects by either mitigating agents or growth factors on human bone marrows. The major accomplishments in 2008 were (1) three potential deliverables as described, (2) elucidating the mechanism of radiation injury to erythroid progenitor and precursor cells by the in vivo and ex vivo comparisons in C57BL/6 mice, and (3) elucidating the cell kinetics of precursor and progenitor cells in human bone marrow using the 3-D culture system for human bone marrow. The work during 2009 has led to the filing of two patent applications and the generation of data to successfully compete and obtain research contracts.
PROJECT 5
An exciting development has been the detection and characterization of gamma-H2AX foci after irradiation at low doses. These studies can now be done by a number of methods including in vitro and in vivo models. The top accomplishments of 2008 were the elucidation of a dose response relationship for the micronucleus (MN) assay and, significantly, the development of robust technique for in vivo analysis of IRIF.In 2009, our major accomplishment is development of a novel 3D microscopy technique for completing DNA repair foci measurements in vivo.
Okunieff P, Swarts S, Keng P, Sun W, Wang W, Kim J, Yang S, Zhang H, Liu C, Williams JP, Huser AK, Zhang L. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol. 2008;614:165-78. Review. [PubMed Abstract]
 

Recent CBARMFI Communications

CBARMFI Publications & Presentations (2008-present)

1. Baumann M, Krause M, Hill R. Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer. 2008 Jul;8(7):545-54.
2. Bemis JC, Chen Y, Bryce, SM, Phonethepswath, S, Chen R, Hyrien O, Peslak S, Palis J, Okunieff P, Dertinger SD. Rapid Radiation Exposure Assessment Accomplished via a Hematotoxicity Matrix. Society of Toxicology Meeting 2009, Baltimore MD.
3. Bentzen Søren M., Matthew Parliament, Joseph O. Deasy, Adam Dicker, Barry S. Rosenstein, Jacqueline Williams: Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy in a QUANTEC perspective. Submitted to International Journal of Radiation Oncology, Biology and Physics (2008).
4. Bhogal N, Jalali F, Bristow RG. Microscopic imaging of DNA repair foci in irradiated normal tissues. Int J Radiat Biol. 2009 Mar 18:1-15
5. Bhogal Nirmal, Pavel Kaspler, Farid Jalali, Ollivier Hyrien, Rui Chen, Richard P. Hill and Robert G. Bristow. Late residual Ah2ax FOCI in murine skin are dose-responsive and predict radiosensitivity in vivo. Radiation Research, Submitted 2009.
6. Black PJ, Swarts SG. Ex Vivo Analysis of Irradiated Finger Nails: Chemical Yields and Properties of Radiation-Induced and Mechanically-Induced Radicals. Health Physics 2009, in press.
7. Bristow RG. Biomarkers of clinical trials using molecular inhibitors and radiotherapy: state-of-the-art. Preface. Cancer Metastasis Rev. 2008 Sep;27(3):337-8
8. Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, and Dertinger SD. Automated Micronucleus Analysis in peripheral Reticulocytes for Radiation Biodosimetry. BioDose 2008 Meeting, Dartmouth Medical College, Hanover, NH, September 7-10, 2008.
9. Chen Y, Tsai Y, Nowak I, Wang N, Hyrien O, Wilkins R, Ferrarotto C, Sun H, and Dertinger SD. Validating high throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model. Health Physics (in press) 2009.
10. Demidenko E, Williams B, Swartz H. Oral Presentation. Radiation dose prediction using time to emesis data in the case of nuclear terrorism. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
11. Demidenko E, Williams BB, Swartz HM. Radiation dose prediction using time to emesis data in the case of nuclear terrorism. Radiation Research 171: 310-319; 2009.
12. Dertinger SD, Bemis JC, Phonethepswath S, Tsai Y, Nowak I, Hyrien O, Palis J, Chen Y. Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: Effect of age. Mutat. Res.: Genet. Toxicol. Environ. Mutagen. (in press) 2009.
13. Dong R, Williams BB, Kmiec M, Demidenko E, Sucheta A, Raynolds T, Nicolalde J, Lariviere JP, Lesniewski P, Burke G, Swartz HM. Estimation of Radiation Doses of Teeth Using In Vivo EPR Spectroscopy. Poster Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
14. Dong R, Williams BB, Kmiec M, Demidenko E, Sucheta A, Raynolds T, Nicolalde J, Lariviere JP, Lesniewski P, Burke G, Swartz H.M. Estimation of Radiation Doses of Teeth Using In Vivo EPR Spectroscopy. Oral Presentation. EPR2008, September 28-30, 2008. Fukuoka, Japan.
15. Dong R, Williams BB, Kmiec M, Demidenko E, Sucheta A, Raynolds T, Nicolalde J, Lariviere JP, Lesniewski P, Burke G, Swartz H.M. Estimation of Radiation Doses of Teeth Using In Vivo EPR Spectroscopy. Poster Presentation. University of Rochester, James P. Wilmot Cancer Center, 13th annual scientific Symposium. October 23, 2008, Rochester, NY
16. Gevorgyan A, Sukhu B, Alman BA, Bristow RG, Pang CY, Forrest CR. Radiation effects and radioprotection in MC3T3-E1 mouse calvarial osteoblastic cells. Plast Reconstr Surg. 2008 Oct;122(4):1025-35.
17. Goff JP, Shields DS, Seki M, Serah Choi S, Michael W. Epperly MW, Dixon T, Wang H, Bakkenist CJ, Dertinger SD, Torous DK, Wittschieben J, Wood RD, and Greenberger JS. Lack of DNA polymerase (POLQ) radiosensitizes bone marrow stromal cells in vitro and increases reticulocyte micronuclei following total body irradiation. Radiat. Res. (in press) 2009.
18. Gougelet R. A View from the Trenches: Emergency Medical Response Plans. Oral Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008
19. Gougelet RM; Rea ME; Nicolalde RJ; Geiling JA; Swartz HM. The View From The Trenches: Emergency Medical Response Plans And The Need For EPR Screening. Health Physics; 2009 (In Press).
20. Gui J, Williams BB, He X, Li H, Ruuge A, Wilcox DE, Swartz HM. Spectral Decomposition and Quantification in Fingernail/Toenail EPR Dosimetry. Poster Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
21. Gurung A, Uddin F, Hill RP, Ferguson PC, Alman BA. Beta-catenin is a mediator of the response of fibroblasts to irradiation. Am J Pathol. 2009 Jan;174(1):248-55
22. He X, Gui J, Li H, Ruuge A, Wilcox D, Williams B, Swartz H. Investigation of the Mechanically Induced EPR Signals in Fingernails/Toenails. Poster Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
23. Hernady Eric, Carl Johnston, Christina Reed, Sally Thurston, Jacob N. Finkelstein, Jacqueline P. Williams. Late inflammatory response following low dose radiation to the lung. Presented at 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
24. Johnston C.J., J.N. Finkelstein, E. Hernady, C. Reed, and J.P. Williams. Radiation combined injury: radiation exposure in combination with infection. Presented at 50th Annual Meeting of American Society for Therapeutic Radiology and Oncology, Boston, September 20-24, 2008.
25. Johnston Carl J., Eric Hernady, Christina Reed, Bruce M. Fenton, Jacob N. Finkelstein, Jacqueline P. Williams. Role of IL1 and inflammatory cell recruitment in radiation-induced pulmonary late effects. Submitted to Radiation Research. Under revision (2009).
26. Johnston Carl J., Eric Hernady, Christina Reed, Sally W. Thurston, Jacob N. Finkelstein, Jacqueline P. Williams: Early alterations in pulmonary cytokine expression: surrogate markers in adult versus children following a radiation event. Submitted to Radiation Research (2009).
27. Johnston Carl, Eric Hernady, Christina Reed, Sally Thurston, Thomas Morgan, Jacqueline P. Williams, Jacob N. Finkelstein. Pulmonary response to internal contamination: a model for a RDD. Presented at 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
28. K. M., S. Fisher, J. Adams, M. Janelsins, O. Palesh, T. Darling, L. Peppone, C. Heckler, J. Williams, G. Morrow. Cytokine-mediated changes associated with improvements in cancer-related fatigue induced by exercise: Results from a randomized pilot study of cancer patients receiving radiotherapy. Submitted to ASTRO 2009.
29. Kaspler P., Hyrien O., Hill R.P. Dynamics of micronuclei in mouse skin fibroblasts after gamma irradiation. Health Physics. Submitted 2009.
30. Li H, He X, Ruuge A, Gui J, Williams B, MacVeagh T, Wilcox DE, Swartz HM. The Impact of Hydration and Microwave Power on EPR Signals in Fingernails/Toenails. Poster Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
31. Liu SK, Olive PL, Bristow RG. Biomarkers for DNA DSB inhibitors and radiotherapy clinical trials. Cancer Metastasis Rev. 2008 Sep;27(3):445-58. Review.
32. Manning C M, C J Johnston, E Hernady, J P Williams, and J N Finkelstein. The Effects of Irradiation on the Lung Inflammatory Response Induced by LPS Inhalation. Submitted to the Radiation Research 2009 meeting in Savannah, Georgia, Oct 3-7, 2009.
33. Mishra KP, Ahmed M, Hill RP. Low-dose radiation effects on human health with implications to radioprotection and cancer radiotherapy. Int J Radiat Biol. 2008 May;84(5):441-4
34. Mustian Nicolalde RJ, Gougelet RM, Rea M, Williams BB, Dong R, Kmiec MM, Lesniewski P, Swartz HM. EPR Dosimetry as a Screening Tool for the Triage of Mass Casualties after a Nuclear Catastrophic Event: Technical and System Considerations. Health Physics; 2009 (In Press).
35. Nicolalde RJ, Gougelet RM, Swartz HM. EPR Spectroscopy for the Process of Triaging Mass Casualties after a Catastrophic Nuclear Event: A Simulated Exercise. Poster Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
36. Okunieff P, Huser AK. “Late Radiation Injury: Exposures and Treatments,” In: Radiation Injury. Shrieve D, editor. Lippincott, Williams & Wilkins; Philadelphia. In press (2009).
37. Okunieff P, Swarts S, Keng P, Sun W, Wang W, Kim J, Yang S, Zhang H, Liu C, Williams JP, Huser AK, Zhang L. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol 2008; 614: 165-78.
38. Okunieff P, Swarts S, Keng P, Sun W, Wang W, Kim J, Yang S, Zhang H, Liu C, Williams JP, Huser AK, Zhang L. Antioxidants reduce consequences of radiation exposure. Adv Exp Med Biol 2008; 614: 165-78.
39. Okunieff P, Yuhchyau Chen, David J. Maguire, Amy K. Huser. Molecular markers of radiation-related normal tissue toxicity. Clinical and Metastasis Reviews. 27(3):363-74 (2008).
40. Okunieff P, Yuhchyau Chen, David J. Maguire, Amy K. Huser. Molecular Markers of Radiation-related Normal Tissue Toxicity. Clinical and Metastasis Reviews. 2008 Sep;27(3):363-74.
41. P. Kaspler, M. Pintilie and R. P. Hill Dynamics of Micronuclei in Rat Skin Fibroblasts after X Irradiation. Radiation Research, in press (2009).
42. Pintilie M, Iakovlev V, Fyles A, Hedley D, Milosevic M, Hill RP. Heterogeneity and power in clinical biomarker studies. J Clin Oncol. 2009 Mar 20;27(9):1517-21.
43. Pollock J, Williams BB, Swartz HM, Kmiec M, Corliss BA, Sidabras J. Finite Element Analysis of Surface Loop Resonators for EPR Dosimetry. Poster Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
44. Pollock JD, Williams BB, Sidabras J, Grinberg O, Salikhov I, Lesniewski P, Kmiec M, Swartz HM. Surface Loop Resonator Design for In Vivo EPR Tooth Dosimetry using Finite Element Analysis. Health Physics; 2009 (In Press).
45. Rea ME, Gougelet RM, Nicolalde RJ. Proposed Triage Categories Using High Accuracy Retrospective Biodosimetry Methods. Poster Presentation. . BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
46. Rea ME; Gougelet RM; Nicolalde RJ; Geiling JA; Harold M Swartz HM. Proposed Triage Categories Using High Accuracy Biodosimetry Methods. Health Physics; 2009 (In Press)
47. Reyes RA, Romanyukha A, Trompier F, Mitchell CA, Clairand I, De T, Benevides LA and Swartz HM. Electron Paramagnetic Resonance in Human Fingernails: The Sponge Model Implication. Radiat. Environ. Biophys. 47:515-516 (2008).
48. Romanyukha A, Reyes RA, Trompier F, Benevides LA, Swartz HM. Fingernail Dosimetry: Current Status and Perspectives. Oral Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
49. Rosenstein BS, Held KD, Rockwell S, Williams JP, Zeman EM. American Society for Radiation Oncology (ASTRO) survey of radiation biology educators in US and Canadian radiation oncology residency programs. Int J Radiat. Oncol. Biol. Phys. In press (2009).
50. Sun H, Wu JHD, Dertinger S, Chen Y. Micronucleus induction in reticulocytes from long-term bone marrow cultures after gamma radiation exposure. Health Physics, Under Review 2009.
51. Sun W, Wang W, Kim J, Keng P, Yang S, Zhang H, Liu C, Okunieff P, Zhang L. Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment. Adv Exp Med Biol 2008; 614: 179-86.
52. Swartz HM, Flood AB, Gougelet RM, Nicolalde RJ, Rea ME, Williams BB. Implementing Biodosimetry Methods for Large Scale Incidents: Technical Considerations. Health Physics; 2009 (In Press).
53. Swartz HM. Optimizing Radiation Therapy by Direct Repeated Measurements of Oxygen in Tumors in Patients. Oral Presentation – Invited Speaker. Radiation Biology Meeting, Jaipur, India. November 10-12, 2008.
54. Swartz HM. "After-the-fact Biodosimetry, Why & How (and What Additionally is Needed)." Oral Presentation - Invited Speaker. Medical College of Wisconsin—The Center for Medical Countermeasures against Radiological Terrorism, April 1-2, 2009, CENTRII '09.
55. Swartz HM. Achieving Requirements for Dosimetry for Management of Potential Radiation Exposures to a Large Population Using EPR Dosimetry. Poster Presentation. Radiation Biology Meeting, Jaipur, India. November 10-12, 2008.
56. Swartz HM. After-the-fact Biodosimetry for Management of Unplanned Clinically Significant Exposures to Ionizing Radiation. Oral Presentation – Invited Speaker and Session Chair. Nuclear Medical Defense Conference, Munich, Germany. February 12, 2009.
57. Swartz HM. Clinical EPR Oximetry. Oral Presentation - Invited Speaker. Paul Scherrer Institute, Zurich, Switzerland, February 9, 2009.
58. Swartz HM. Overview of BioDose 2008 and the Needs for Biodosimetry. Oral Presentation. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
59. Swartz HM. Summary of the Presentation and Conclusions from Biodose. Oral Presentation – Invited Speaker. IRPA12 (International Congress of the International Radiation Protection Association, Buenos Aires, Argentina. October 19-24, 2008.
60. Swartz HM. Triage of Populations Potentially Exposed to Clinically Significant Doses of Ionizing Radiation Using EPR Measurements of Teeth. Poster Presentation. IRPA12 (International Congress of the International Radiation Protection Association, Buenos Aires, Argentina. October 19-24, 2008.
61. Swartz HM. Triage of Populations Potentially Exposed to Clinically Significant Doses of Ionizing Radiation Using In Vivo EPR Measurements of Fingernails and Toenails. Poster Presentation. HM Swartz. IRPA12 (International Congress of the International Radiation Protection Association, Buenos Aires, Argentina. October 19-24, 2008.
62. Swartz HM. Tumor Oxygenation in the Clinical Setting Assessed by EPR Technology. Oral Presentation -Invited Guest Speaker. Klinik fur Strahlentherapie, Munich, Germany, February 13, 2009.
63. Swartz HM. Use of EPR for Dosimetry for Management of Potential Radiation Exposures to Large Population. Oral Presentation. Radiation Research Society Meeting, Boston, MA. September 21-24, 2008
64. Tian Yeping, Shanmin Yang, Yongbing Cao, Liangjie Yin, Lei Zhang, Mei Zhang, Kunzhong Zhang, Steven Swarts, Bruce Fenton, Paul Okunieff and Lurong Zhang. Plasma SP-D as a Marker for Radiation Lung Injury and Treatment Outcome. 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
65. Trompier F, Romanyukha A, Cornak L, Calas C, LeBlanc B, Mitchell C, Swartz HM and Clairand I, "Electron Paramagnetic Resonance Radiation Dosimetry in Fingernails," Radiat. Measurement. In Press (2009).
66. Veenema TG, Walden B, Feinstein N, Williams JP: Factors affecting hospital-based nurses’ willingness to respond to a radiation emergency. Disaster Medical Public Health Preparedness 2 (4): 224-229, 2008.
67. Wilcox D, Xiaoming H, Gui J, Ruuge A, Li H, Williams B, Swartz H. Oral Presentation. Dosimetry Based on EPR Spectral Analysis of Fingernail Clippings. In Vivo EPR Tooth Dosimetry. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
68. Wilcox DE, He X, Gui J, Ruuge AE, Li H, Williams BB, Swartz HM. Dosimetry Based on EPR Spectral Analysis of Fingernail Clippings. Health Physics; 2009 (In Press)
69. Williams BB, Dong R, Kmiec M, Burke G, Corliss B, Demidenko E, Gladstone D, Grinberg O, Nicolalde RJ, Pollack J, Raynolds T, Salikhov IK, Sucheta A, Lesniewski P, Swartz HM. Development of In Vivo Tooth EPR for Individual Radiation Dose Estimation and Screening. Health Physics; 2009 (In Press).
70. Williams J.P., T. Wright, J.N. Finkelstein, C.J. Johnston. Effect of Radiation Exposure in Combination with Infection: Relevance to Immunosuppression. Submitted to the Radiation Research 2009 meeting in Savannah, Georgia, Oct 3-7, 2009.
71. Williams Jacqueline, Carl Johnston, Eric Hernady, Christina Reed, Jen-nie Miller, Cathy Zimmerman, Jacob N. Finkelstein. Mitigating lung late effects: Development of murine test models and agent assessment. Submitted to the Radiation Research 2009 meeting in Savannah, Georgia, Oct 3-7, 2009.
72. Williams JP, Brown S, Georges G, Hauer-Jensen M, Hill RP, Huser AK, Kirsch D, MacVittie T, Mason KA, Medhora M, Moulder J, Okunieff P, Otterson M, Robbins ME, Smathers J, and McBride WH. CMCR Animal Models Workshop Report. Radiation Research (in press 2009).
73. Williams, B.B., R. Dong, M. Kmiec, G. Burke, B. Corliss, E. Demidenko, O. Grinberg, J. Nicolalde, J. Pollack, T. Raynolds, I. Salikhov, A. Sucheta, P. Lesniewski and H. Harold Swartz. Oral Presentation. In Vivo EPR Tooth Dosimetry. BioDose 2008 - 7th International Symposium on ESR Dosimetry and Applications, Dartmouth College, Hanover, NH. September 7-11, 2008.
74. Woodward WA, Bristow RG. Radiosensitivity of cancer-initiating cells and normal stem cells (or what the Heisenberg uncertainly principle has to do with biology). Semin Radiat Oncol. 2009 Apr;19(2):87-95.
75. Yang Shanmin, Hengshan Zhang, Mei Zhang, Weimin Sun, Wei Wang, Chaomei Liu, Kunzhong Zhang, Yougbing Cao, Yeping Tian, Zhang, Lei, Yin, Liangjie, Paul Okunieff and Lurong Zhang. Triptolide Mitigates Radiation-induced Pneumonitis and Lung Fibrosis. 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
76. Yang Shanmin, Mei Zhang, Liangjie Yin, Brian Smith, Kunzhong Zhang, Hengshan Zhang, Weimin Sun, Wei Wang, Chaomei Liu, Charles Francis, Steven Swarts, Paul Okunieff and Lurong Zhang. FGF2 Peptide Mitigates Platelet and Bone Marrow Radiation Damage. 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
77. Zhang Hengshan, Weimin Sun, Shanmin Yang, Mei Zhang, Wei Wang, Chaomei Liu, Kunzhong Zhang, Steven Swarts, Bingrong Zhang, Bruce M. Fenton, Peter Keng, David Maguire, Paul Okunieff, and Lurong Zhang. B1 Sequence-based real-time Quantitative PCR: A sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation. Int J Radiat Oncol Biol Phys. in press (2009).
78. Zhang Lei, Liangjie Yin, Mei Zhang, Shanmin Yang, Yongbing Cao, Yeping Tian, Kunzhong Zhang, Steven Swarts, Bruce Fenton, Paul Okunieff and Lurong Zhang: Differentiated alterations of Infiltrated Lung Inflammatory Cells and Agent Effect on Radiation Pneumonitis. 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
79. Zhang Lei, Mei Zhang, Yunqing Ma, Aiguo Zhang, Paul Okunieff, Lurong Zhang. A new biodosimetric method: Branched DNA based quantitative detection of plasma B1 DNA in mouse. Submitted: Int J Radiat Oncol Biol Phys (2009).
80. Zhang Lurong, Shanmin Yang, Kunzhong Zhang, Mei Zhang, Liangjie Yin, Hengshan Zhang, Yongbing Cao, Yeping Tian, Lei Zhang, Liangjie Yin, Chaomei Liu, Steven Swarts, Bruce Fenton and Paul Okunieff: Neuropeptide Y Mitigates Bone Marrow Radiation Damage. 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
81. Zhang Mei, Liangjie Yin, Shanmin Yang, Hengshan Zhang, Yongbing Cao, Yeping Tian, Lei Zhang, Kunzhong Zhang, Steven Swarts, Bruce Fenton, Lurong Zhang and Paul Okunieff: FGF-P Mitigates Radiation Combined Injury. 54th Annual Meeting of Radiation Research Society, Boston, September 20-24, 2008.
82. Zhang Mei, Steve Swarts, Liangjie Yin, Chaomei Liu, Yeping Tian, Yongbing Cao, Mike Swarts, Shanmin Yang, Steven B. Zhang, Kunzhong Zhang, Shaoqing Ju, Peter Keng, Sadasivan Vidyasagar, Paul Okunieff and Lurong Zhang. Anti-oxidant Properties of Quercetin. ISOTT 2009, Cleveland, July 5-9, 2009.
83. Zhang, L., Weimin Sun, Jianjun Wang, Mei Zhang, Shanmin Yang, Yeping Tian, Sadasivan Vidyasagar, Louis A Pena, Kunzhong Zhang, Yongbing Cao, Liangjie Yin, Wei Wang, Lei Zhang, Katherine L. Schaefer, Lawrence J. Saubermann, Steven Swarts, Bruce Fenton, Peter Keng, Paul Okunieff. Mitigation Effect of an FGF-2 Peptide on the Acute Gastrointestinal Syndrome After High Dose Ionizing Radiation. Submitted to Int J Radiat Oncol Biol Phys (2009).
84. Zhang Steven B., Shanmin Yang, Ying Su, Hengshan Zhang, Mei Zhang, Sadasivan Vidyasagar, Peter Salzman, Weimin Sun, Wei Wang, Chaomei Liu, Liangjie Yin, Kunzhong Zhang, Lie Zhang, Yungbing Cao, Yeping Tian, Steven Swarts, Bruce M. Fenton, Peter Keng, Paul Okunieff, Lurong Zhang. Biodosimetry of Ionizing Radiation: Direct Measurement of Plasma DNA by PicoGreen Assay. Submitted: Radiat Res (2009).
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